Abstract Details

Title High-definition Transcranial Direct Current Stimulation Targeting Different Brain Regions Leads to Differential Effects on Cognitive Functions and Event-related Potentials in Patients with Primary Progressive Aphasia

Topic Neuro-rehabilitation

Presentation(s) P7 - Poster Session 7 (5:00 PM-6:00 PM)

Poster/Presentation
Number 4-005

Objective

We investigated how high-definition transcranial direct current stimulation (HD-tDCS) targeting separate brain regions could change cognitive performance and brain responses in primary progressive aphasia (PPA) as a novel approach of intervention.

Background Cognitive functions are often impaired in PPA. However, most of the existing studies focus on alleviating speech/language symptoms. There have been no studies so far examining how HD-tDCS may change non-speech/language cognition along with brain responses measured by electroencephalography (EEG).

Design/Methods This was an open-label study entailing 10 sessions of active HD-tDCS in eight PPA patients (age = 73.4 ± 3.6, 2 F), targeting the left inferior frontal gyrus (LIFG, n = 4) or pre-supplementary motor area (preSMA, n = 4). All underwent baseline and post-treatment evaluations with a neuropsychological battery (immediately and 8 weeks post) and EEG Go-NoGo tasks (immediately post). Midline N200/P300 event-related potential (ERP) components were calculated for EEG. Raw scores from neuropsychological and ERP measures were evaluated using mixed 2 x 2 ANOVAs.

Results

For immediate effects, the LIFG group improved significantly in working memory (p = 0.035) compared to the preSMA group (p = 0.391). Both groups improved in non-verbal learning (p = 0.015) and processing speed (p = 0.004), but not in attention, verbal learning or executive function (all ps > 0.05). These immediate effects were sustained at 8-week post-treatment. For ERP, there was a significant post-treatment decrease of P300 amplitude (NoGo – Go) in the LIFG group (p < .001), qualitatively more similar to normal controls at post-treatment testing, while no significant change was found in the pre-SMA group (p = .976).

Conclusions

The present research shows preliminary evidence to support traditional and alternate stimulation sites to treat cognitive deficits other than speech/language in individuals with PPA and informs future designs of non-invasive brain stimulation in treating cognitive symptoms in PPA.

Authors/Disclosures
Hsueh-Sheng Chiang, MD, PhD (Beth Israel Deaconess Medical Center) PRESENTER	The institution of Dr. Chiang has received research support from NIH/NIDCD. The institution of Dr. Chiang has received research support from Texas Alzheimer's Research and Care Consortium.
Christine S. Dugas, PhD	Dr. Dugas has nothing to disclose.
Paulina V. Devora, MS	Mrs. Devora has nothing to disclose.
Katelyn A. Lucas-Mendoza	Mrs. Lucas-Mendoza has nothing to disclose.
Christine H. Abasi, MS - SLP	Miss Abasi has nothing to disclose.
Ashna Adhikari	Ms. Adhikari has nothing to disclose.
Alexander Frolov, MD (UT Southwestern Medical Center)	Dr. Frolov has nothing to disclose.
Trung P. Nguyen, MD (UT Southwestern Medical Center)	The institution of Dr. Nguyen has received research support from National Institute on Aging. The institution of Dr. Nguyen has received research support from Texas Alzheimer's Research and Care Consortium. The institution of Dr. Nguyen has received research support from Biogen.
Brendan J. Kelley, MD, FAAN (University of Texas Southwestern)	Dr. Kelley has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Kelley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Labcorp. Dr. Kelley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Esai.
John Hart, MD (The University of Texas At Dallas)	The institution of Dr. Hart has received research support from Department of Defense.

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