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Abstract Details

Relationships Between Heart-health, Cardiorespiratory Fitness, and Attention-related Activation in Adults with Idiopathic Generalized Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
P7 - Poster Session 7 (5:00 PM-6:00 PM)
9-007

To examine the relationship between heart-health, cardiorespiratory fitness and executive attention during a functional magnetic resonance imaging flanker task (fMRI-FT) in adults with idiopathic generalized epilepsy (IGE).
People with IGE suffer from comorbidities including attention impairments that may be mitigated by health and fitness. We hypothesize that increased heart-health and cardiorespiratory fitness will be associated with improved attention in adults with IGE.

Thirty-six participants with IGE (20 females; ages 18-50, mean=29.5) completed an fMRI-FT scan and cardiorespiratory fitness (VO2max) testing. Resting systolic blood pressure (sysBP) collected before MRI assessed heart-health. During fMRI-FT, participants indicated via button press if the target was incongruent (INC) or congruent (CON) relative to surrounding stimuli, and accuracy was recorded. FMRI-FT data was analyzed with AFNI. A one sample t-test covarying for seizure frequency (self-reported for all seizure types; 23 seizure-free) was conducted to create a statistical parametric map of attention-related fMRI-FT group activation. Pearson correlations assessed relationships between statistically-significant attention-related fMRI activation (corrected p<0.05), INC and CON accuracy, sysBP, and VO2max. 

There was significant attention-related fMRI-FT activation in the left midline cerebellum (LCer) and right superior parietal lobule (RSPL).  LCer activation showed significant correlation with CON (r=-0.539; p=0.0007) and INC (r=-0.460; p=0.0047) accuracy. RSPL activation showed significant correlation with INC (r=-0.478; p=0.0032) but not CON (r=-0.201; p=0.239) accuracy. LCer activation showed significant correlation with sysBP (r=0.353; p=0.0345) and a non-significant trend with VO2max (r=-0.281; p=0.0965).

Decreased LCer activation was associated with better overall attentional performance on the fMRI-FT, while decreased RSPL was associated with improved accuracy on the more difficult INC condition. The significant relationship between decreased sysBP (indicating better heart-health) and decreased LCer activation, along with corresponding LCer relationships with fMRI-FT performance, suggest a role of these factors in potentially mitigating attention impairments in IGE. Further research is needed to better understand these relationships.
Authors/Disclosures
Jakaiya S. Bryant
PRESENTER 		Miss Bryant has nothing to disclose.
Ricardo Ortiz-Braidot, MS Mr. Ortiz-Braidot has nothing to disclose.
Jerzy P. Szaflarski, MD, PhD, FAAN (University of Alabama At Birmingham) Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LivaNova Inc. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PureTech Health. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Gidley, Sarli & Marusak, LLP. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Law Firm. Dr. Szaflarski has stock in AdCel Biopharma, LLC. Dr. Szaflarski has stock in iFovea.
Thomas Buford, PhD Dr. Buford has nothing to disclose.
Lawrence W. Ver Hoef, MD Dr. Ver Hoef has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Bowling & Christiansen. The institution of Dr. Ver Hoef has received research support from NIH. The institution of Dr. Ver Hoef has received research support from AES.
Adam M. Goodman, PhD Dr. Goodman has nothing to disclose.
Roy C. Martin, PhD Prof. Martin has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elseiver Publishers. The institution of Prof. Martin has received research support from NIH.
Charity J. Morgan, PhD Dr. Morgan has nothing to disclose.
Anna Moyana, GR, CERT -CNIN Mrs. Moyana has nothing to disclose.
Jennifer B. Pilkington Mrs. Pilkington has nothing to disclose.
Amy Miller, ACSM-CEP Mrs. Miller has nothing to disclose.
Kären J. Fulton, NP Ms. Fulton has nothing to disclose.
Goutham Selladurai, MBBS Dr. Selladurai has nothing to disclose.
Brandon Mitchell, BS Mr. Mitchell has nothing to disclose.
Yun Lien, MSc Miss Lien has nothing to disclose.
Jane B. Allendorfer, PhD (U of Alabama At Birmingham, Neurology) The institution of Dr. Allendorfer has received research support from National Institutes of Health. The institution of Dr. Allendorfer has received research support from Evelyn F. McKnight Brain Institute. The institution of Dr. Allendorfer has received research support from LivaNova, Inc. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Cleveland Clinic. Dr. Allendorfer has received personal compensation in the range of $0-$499 for serving as a Examiner with University of Auckland. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International League Against Epilepsy. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense. Dr. Allendorfer has a non-compensated relationship as a Scientific Program Committee Member with American Epilepsy Society that is relevant to AAN interests or activities. Dr. Allendorfer has a non-compensated relationship as a Editorial Board Member with Epilepsy and Behavior Reports that is relevant to AAN interests or activities.