ADPKD is associated with an increased risk of IAs, which represents a significant threat due to the potential for rupture and subsequent subarachnoid hemorrhage. Despite this known risk, there is an ongoing debate regarding the necessity of routine screening for IAs in ADPKD patients.

We systematically search PubMed, Embase, Scopus, Web of Science until September, 2024. Two authors assessed independently each study and extracted data. We evaluate the risk of bias using NewCastle Ottawa Scale. A meta-analysis using a random effects model was employed to calculate the pooled prevalence of IAs in ADPKD patients

A total of 23 studies comprising 7,087 participants were included in this meta-analysis, with 8 newly identified studies. The overall prevalence of IAs was 11.0% (95%CI: 8.0%-14.0%; I2 = 91%), with a higher proportion in Japan (18.0%; 9 studies; 943 participants; 95%CI: 13.0%-23.0%; I2 = 53%). High prevalence was also reported in Poland with 16.87% (1 study, 95%CI: 9.49% - 25.76%) and South Korea with 15.98% (1 study, 95%CI: 13.69% - 18.42%).