Using the CDC WONDER multiple cause of death database, hyperlipidemia-related CVD mortality among older adults (65+ years) was examined from 1999-2020. Age-Adjusted Mortality Rates (AAMRs) per 100,000 individuals were calculated. Annual Percentage Change (APC) and trends were analyzed across demographic (gender, race/ethnicity) and regional groups using Joinpoint regression.

Between 1999 and 2020, 123,318 older adults suffered from hyperlipidemia-related CVD deaths in the US. Overall, The AAMR for mortality increased from 5.27 in 1999 and 20.9 in 2020, ascending from 1999 to 2004 (APC: 14.7 [12.3 to 18.6]). Following  a slower rise from 2004 to 2010 (APC: 5.7% [4.1 to 7.6]), the rates stabilized till 2018, with a significant rise from 2018 to 2020 (APC: 13.9 [9.9 to 16.8]) with an average annual percentage decrease of 6.6% (6.3 to 7.1). Males showed higher AAMR than females (14.45 vs 12.63). Non-Hispanic (NH) Blacks had the highest AAMR (14.44), followed by NH Whites (13.49), NH Asians (12.99), and Hispanics (10.78). Regionally, West had the highest AAMR (15.7) and Northeast the lowest (11.4). Additionally, non-metropolitan surpassed metropolitan areas, Vermont showing the highest AAMR (34.98) and Nevada the lowest (6.46).