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Abstract Details

Evaluating the Role of Interferon Gamma in the Hyper Acute Phase of Stroke in a Mouse Model
Cerebrovascular Disease and Interventional Neurology
P8 - Poster Session 8 (8:00 AM-9:00 AM)
14-016
Evaluating inflammatory mediators in transient middle cerebral artery occlusion (tMCAO)
Strokes are one of the leading causes of death- with ischemic strokes being the most common. Typically, this process occurs by which a thrombus or embolus occludes a major vessel within the brain leading to reduced blood flow (ischemia) precipitating damage to brain tissue. Large vessel occlusion is a critical event, in which a rapid response is required to ensure the survival of brain tissue. In a previous study from our lab, human blood samples were collected from pre-ictus and post-ictus from large vessel occlusion samples. This study found increases in interferon gamma in the post-ictus compared to the pre-ictus and intraarterial artery (distal control). There was no significant increase in T-cells. IFN-gamma is involved in the production of various inflammatory mediators, however, in the context of the stroke, it is not known where the IFN-gamma production is sourced from early in the stroke cascade. This study aims to recapture the evidence found in the human study within a mice model to further elucidate the role of interferon gamma following a transient vessel occlusion. 
This study uses oxygen-glucose deprivation in vitro methods and in vivo experiments to evaluate sources of inflammation in the pre-occlusion and post-occlusion blood samples following transient middle cerebral artery occlusion (tMCAO) in mice. 
An increase in IFN-gamma was observed in the mice following transient middle cerebral artery occlusion (tMCAO) in the post-occlusion sample compared to pre-occlusion sample. 

Following transient middle cerebral artery occlusion (tMCAO) in a mouse model, IFN-gamma levels were found to be increased. This suggests that IFN-gamma could play a significant role in exacerbating brain parenchymal damage, particularly in the context of post-large vessel occlusion. Understanding this relationship could be valuable for evaluating care during or after a suspected stroke.

Authors/Disclosures
Safia Sharif
PRESENTER
Miss Sharif has nothing to disclose.
Katherine Hernandez Miss Hernandez has nothing to disclose.
Nathan Jones Mr. Jones has nothing to disclose.
sterling ortega, PhD Dr. ortega has nothing to disclose.