Myopathies can be challenging to recognize and diagnose. While creatine kinase (CK) is often elevated, aldolase may be selectively elevated when CK is normal. Few studies have analyzed the frequency of elevated aldolase levels and how often this finding might guide diagnosis.

Patients with aldolase levels measured for the first time at our medical center between January 2022 and December 2022 were retrospectively reviewed. Aldolase levels and CK levels for each patient were documented. Frequencies of normal or elevated aldolase and normal or elevated CK were calculated. A final diagnosis, including whether a myopathy was present, was determined for each patient with elevated aldolase.