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Abstract Details

Comparisons of Subjective and Objective Motor and Non-motor Symptoms in Isolated REM Sleep Behavior Disorder in the North American Prodromal Synucleinopathy (NAPS) Cohort
Sleep
S3 - Research Advances in Sleep and Clinical Impact (1:48 PM-2:00 PM)
005

To compare self-reported and objective symptoms of motor and non-motor dysfunction in isolated RBD (iRBD) patients with subjective cognitive impairment (iRBD-SCI), quantitative cognitive impairment (iRBD-QCI), and no cognitive impairment (iRBD).

iRBD patients frequently endorse motor and non-motor symptoms without clear objective correlations. Comparisons between subjective motor or non-motor symptoms and objective measures have not been explicitly evaluated in iRBD.

Participants included 268 iRBD, 60 iRBD-SCI and 44 iRBD-QCI from the North American Prodromal Synucleinopathy (NAPS) cohort. iRBD patients had no cognitive complaints, with normal neuropsychological testing; iRBD-SCI had cognitive complaints with normal neuropsychological testing; and iRBD-QCI had no cognitive complaints but abnormal neuropsychological testing. Non-motor symptoms were measured by MDS-UPDRS-I. Subjective and objective motor symptoms were measured by MDS-UPDRS-II and MDS-UPDRS-III, respectively. Subjective autonomic symptoms were assessed with SCOPA-AUT and objective autonomic dysfunction by orthostatic blood pressure drop. Total symptom burden was assessed with the Prodromal Synucleinopathy Rating Scale sum score (PSRS SUM). One-way ANOVA with Tukey’s HSD post-hoc tests determined significant group differences.

iRBD-SCI scored higher on MDS-UPDRS-I than both iRBD-QCI (4.1; 95% CI 1.1–7.0) and iRBD (2.4; 95% CI 0.3–4.5). iRBD-SCI had higher MDS-UPDRS-II than iRBD-QCI (2.7; 95% CI 0.2–5.3), with no differences in objective motor measures. SCOPA-AUT was higher in iRBD-SCI than both iRBD-QCI (5.0; 95% CI 1.5–8.4) and iRBD (3.1; 95% CI 0.6–5.6), with no differences in orthostatic blood pressure drop between groups. iRBD-SCI scored higher on PSRS SUM than iRBD-QCI (3.7; 95% CI 1.5–5.8) and iRBD (2.4; 95% CI 0.9–3.9). iRBD and iRBD-QCI did not differ on any measure.

iRBD-SCI endorse greater subjective motor and non-motor symptomatology than both iRBD-QCI and iRBD patients without differences in objective motor or autonomic functioning. Longitudinal follow-up will be necessary to assess phenoconversion differences between groups.

Authors/Disclosures
Neha V. Reddy, MD
PRESENTER 		Dr. Reddy has nothing to disclose.
Yuzheng Nie, MS Mr. Nie has nothing to disclose.
Hernis De La Cruz Mr. De La Cruz has nothing to disclose.
Chengjie Xiong, PhD (Washington University School of Medicine) Chengjie Xiong has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for DIADEM.
Alon Y. Avidan, MD, MPH, FAAN (David Geffen School of Medicine at UCLA) Dr. Avidan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Avidan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Avadel. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Harmony. Dr. Avidan has received personal compensation in the range of $0-$499 for serving as a Consultant for Merck. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Harmony. Dr. Avidan has received publishing royalties from a publication relating to health care.
Donald L. Bliwise, PhD Prof. Bliwise has nothing to disclose.
Meghan C. Campbell, PhD (Washington University in St. Louis) The institution of Meghan C. Campbell has received research support from NIH. The institution of Meghan C. Campbell has received research support from NIH. The institution of Meghan C. Campbell has received research support from McDonnell Center for Systems Neuroscience. The institution of Meghan C. Campbell has received research support from WUSM Radiology Department. The institution of Meghan C. Campbell has received research support from NIH. Meghan C. Campbell has received personal compensation in the range of $0-$499 for serving as a Grant Reviewer with Parkinson Foundation. Meghan C. Campbell has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense.
Susan Criswell, MD (Washington University) Dr. Criswell has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie.
Albert A. Davis, MD Dr. Davis has nothing to disclose.
Kevin Duff, PhD Dr. Duff has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of the International Neuropsychological Society. Dr. Duff has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for various attorneys.
Jonathan Elliott Jonathan Elliott has nothing to disclose.
Tanis J. Ferman, PhD (Mayo Clinic Jacksonville) Ms. Ferman has nothing to disclose.
Leah K. Forsberg, PhD (Mayo Clinic) Ms. Forsberg has nothing to disclose.
Jean-Francois Gagnon (Centre D'etude Du Sommeil) The institution of Jean-Francois Gagnon has received research support from Canadian Institute of Health Research. The institution of Jean-Francois Gagnon has received research support from Canada Research Chair. The institution of Jean-Francois Gagnon has received research support from National Institutes of Health.
Michael J. Howell, MD, FAAN The institution of Dr. Howell has received research support from National Institutes of Health. Dr. Howell has received publishing royalties from a publication relating to health care.
Daniel Huddleston, MD (Emory University) The institution of Dr. Huddleston has received research support from NIH-NINDS 1K23NS105944-01A1. The institution of Dr. Huddleston has received research support from Michael J. Fox Foundation (MJFF-010556). The institution of Dr. Huddleston has received research support from Lewy Body Dementia Association Research Center of Excellence (Emory). The institution of Dr. Huddleston has received research support from American Parkinson's Disease Association.
Miranda M. Lim, MD, PhD (VA Portland Health Care System) Dr. Lim has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Cognition. Dr. Lim has stock in Applied Cognition. The institution of Dr. Lim has received research support from NIH. The institution of Dr. Lim has received research support from VA. The institution of Dr. Lim has received research support from Department of Defense. The institution of Dr. Lim has received research support from National Science Foundation. Dr. Lim has received publishing royalties from a publication relating to health care.
Jessica Locke, PhD, APRN (OHSU Neurology) Dr. Locke has received personal compensation for serving as an employee of Portland VA Research Foundation.
Jennifer S. McLeland (Washington University School of Medicine) Ms. McLeland has nothing to disclose.
Mitchell G. Miglis, MD, FAAN (Stanford University Medical Center) Dr. Miglis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alight Health. Dr. Miglis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint, LLC. Dr. Miglis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for 2nd MD. Dr. Miglis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz Pharmaceuticals. Dr. Miglis has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Van Cott and Talamante. The institution of Dr. Miglis has received research support from Dysautonomia International. The institution of Dr. Miglis has received research support from National Institute of Health. Dr. Miglis has received publishing royalties from a publication relating to health care.
Toji Miyagawa, MD, PhD (Mayo Clinic) Dr. Miyagawa has nothing to disclose.
Lee E. Neilson, MD Dr. Neilson has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Hart Wagner LLP. Dr. Neilson has received research support from VA ORD - Clinical Science Research and Development. An immediate family member of Dr. Neilson has received research support from NIH - NINDS.
Kendall Nichols, MD (University of Minnesota) Dr. Nichols has nothing to disclose.
Amelie Pelletier (Montreal General Hospital) Ms. Pelletier has nothing to disclose.
Carlos H. Schenck, MD (Minnesota Regional Sleep Disorders Center) Dr. Schenck has received personal compensation for serving as an employee of Physicians' 好色先生al Resource, LLC.. Dr. Schenck has received personal compensation for serving as an employee of Eisai Global Medical Affairs.
Erik K. St. Louis, MD (Mayo Clinic) The institution of Dr. St. Louis has received research support from NIH. Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care.
Oliver R. Sum-Ping, MD Dr. Sum-Ping has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda Pharmaceuticals. The institution of Dr. Sum-Ping has received research support from Avadel Pharmaceuticals. The institution of Dr. Sum-Ping has received research support from American Academy of Sleep Medicine Foundation.
LynnMarie Trotti, MD (Emory University School of Medicine) Dr. Trotti has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for American Academy of Sleep Medicine. The institution of Dr. Trotti has received research support from NIH. Dr. Trotti has received personal compensation in the range of $500-$4,999 for serving as a Speaker with AASM, CHEST, Medscape, SRS Foundation, PER CME, Haymarket CME. Dr. Trotti has received personal compensation in the range of $0-$499 for serving as a DSMB member with NIH. Dr. Trotti has a non-compensated relationship as a Medical advisory board member with Hypersomnia Foundation that is relevant to AAN interests or activities. Dr. Trotti has a non-compensated relationship as a Board member with AASM Foundation that is relevant to AAN interests or activities. Dr. Trotti has a non-compensated relationship as a Board member with ABSM that is relevant to AAN interests or activities.
Aleksandar Videnovic, MD, MSc, FAAN (MGH Neurological Clinical Research Institute) Dr. Videnovic has nothing to disclose.
Ronald Postuma, MD (Montreal General Hospital) Dr. Postuma has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche, Biogen, Takeda, Theranexus, GE, Jazz, Curasen, Paladin, Inception Sciences, Phytopharmics, Vaxxinity, Merck. Dr. Postuma has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen/Partners. The institution of Dr. Postuma has received research support from CIHR, Weston Foundation, Webster Foundation, Roche, MJFF, Parkinson Canada, FRSQ, NIH.
Yo-El Ju, MD The institution of Dr. Ju has received research support from National Institutes of Health.
Julie A. Fields, PhD (Mayo Clinic) The institution of Dr. Fields has received research support from National Institutes of Health. The institution of Dr. Fields has received research support from Patient-Centered Outcomes Research Institute.
Bradley F. Boeve, MD, FAAN (Mayo Clinic) Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
Stuart J. McCarter, MD (Mayo Clinic) The institution of Dr. McCarter has received research support from NIH. The institution of Dr. McCarter has received research support from American Academy of Sleep Medicine Foundation.