Abstract Details

Title Longitudinal Normative Weight Trajectories in Parkinson’s Disease

Topic Movement Disorders

Presentation(s) S43 - Movement Disorders: Biomarkers, Mechanisms, and Pathophysiology (2:12 PM-2:24 PM)

Poster/Presentation
Number 007

Objective To establish longitudinal normative weight data for Parkinson’s disease (PD) patients, enabling early identification of patients at risk for significant weight loss who may benefit from clinical intervention.

Background PD patients tend to lose weight faster than age-matched controls. Low weight in PD is consistently linked to frailty, malnutrition, and increased morbidity and mortality. Despite its clinical relevance, there is a lack of normative longitudinal data for weight trajectories in PD. Comparative benchmarks using healthy aging controls are also lacking, impeding the ability to identify patients requiring intervention for weight decline.

Design/Methods We analyzed a retrospective, longitudinal cohort of PD patients from the University of Pennsylvania, comparing their weight to National Center for Health Statistics (NCHS) National Health and Nutrition Examination Survey (NHANES) data representative of aging in the United States. A mixed model was used to control for patient age, disease duration, and sex. Population-level weight and percent-change in weight was analyzed as a function of disease duration and age- and sex-matched NHANES projections served as a control reference.

Results PD patients consistently weigh less than NHANES controls across age bins and exhibit a significantly greater reduction in body weight both early and throughout disease progression. These patterns are robust after adjustment for baseline age and sex. We have applied these data to develop tools that calculate weight percentiles and weight trajectory percentiles for individual PD patients, enabling risk stratification and clinical decision support.

Conclusions These results require validation in additional cohorts but provide a foundation for future standardized care pathways and targeted intervention for weight loss in PD.

Authors/Disclosures
Robert S. Eisinger, MD, PhD PRESENTER	The institution of Dr. Eisinger has received research support from NIH.
Ellie D. Gabriel	Miss Gabriel has nothing to disclose.
Joyce Lee, MD (University of Pennsylvania)	No disclosure on file

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