Abstract Details

Title Phase II/III Study of Ulviprubart in Inclusion Body Myositis: Study Design, Patient Characteristics, and Topline Results

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) S7 - Updates on Muscle Disorders (4:42 PM-4:54 PM)

Poster/Presentation
Number 007

Objective

Describe the study design and results of a phase 2/3 study of ulviprubart for treatment of inclusion body myositis (IBM).

Background

IBM is a rare, progressive disorder characterized by invasion of muscle by highly differentiated cytotoxic CD8+ T cells. IBM can cause difficulty walking, loss of grip strength, and dysphagia. There are no pharmacological treatments approved for IBM. Ulviprubart, a humanized monoclonal antibody, selectively depletes cytotoxic CD8+ KLRG1+ T cells by targeting KLRG1 expressed on most IBM-muscle–infiltrating T cells.

Design/Methods This randomized, double-blind, placebo-controlled trial (NCT05721573) included patients aged ≥40 years with an IBM diagnosis otherwise fulfilling 2011 European Neuromuscular Center criteria. Ulviprubart (0.5 or 2.0 mg/kg) or placebo (1:1:1) was administered subcutaneously every 8 weeks for 76 weeks, with the option to receive treatment at 2.0 mg/kg in an open-label extension study. Efficacy endpoints included mean changes from baseline to week 76 in Inclusion Body Myositis Functional Rating Scale (IBMFRS; primary), manual muscle testing (MMT) of 23 muscle groups converted to a Kendall score, hand grip and quadriceps strength by dynamometry, and modified Timed Up and Go (mTUG). Safety monitoring included assessment of treatment-emergent adverse events.

Results

Overall, 272 patients were enrolled. Mean (SD) patient age at baseline was 68.1 (7.8) years, and 186 patients were male (68%). Mean (SD) age at diagnosis was 65.1 (8.1) years. Mean (SD) baseline IBMFRS score was 27.3 (5.0); 14 patients had baseline IBMFRS scores of <20, 63 had scores of 20−24, and 195 had scores of ≥25. Mean (SD) baseline values for MMT, grip strength (dominant), quadriceps strength (dominant), and mTUG score were 7.8 (1.2), 11.7 (7.0) kg, 11.0 (7.6) kg, and 0.32 meters/second, respectively.

Conclusions This is the largest prospective interventional study of patients with IBM with a range of clinically significant disease burden. Topline efficacy and safety results will be presented.

Authors/Disclosures
Namita Goyal, MD, FAAN (University of California, Irvine) PRESENTER	Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Annexon. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abcuro. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Souffle. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for CSL Behring. Dr. Goyal has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Argenx. Dr. Goyal has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Amgen. The institution of Dr. Goyal has received research support from Fulcrum. The institution of Dr. Goyal has received research support from Healey Platform. The institution of Dr. Goyal has received research support from Medicinova. The institution of Dr. Goyal has received research support from Transposon. The institution of Dr. Goyal has received research support from Abcuro. The institution of Dr. Goyal has received research support from Calico. The institution of Dr. Goyal has received research support from Clene. The institution of Dr. Goyal has received research support from Janssen. The institution of Dr. Goyal has received research support from PepGen. The institution of Dr. Goyal has received research support from PTC. The institution of Dr. Goyal has received research support from Roche. The institution of Dr. Goyal has received research support from Sanofi. The institution of Dr. Goyal has received research support from Prilenia. The institution of Dr. Goyal has received research support from RAPA. The institution of Dr. Goyal has received research support from Avidity. Dr. Goyal has received publishing royalties from a publication relating to health care.
Pedro Machado, MD, PhD	Prof. Machado has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie, Abcuro, Eli Lilly, Galapagos/Alfasigma, Greywolf, Novartis, Orphazyme, Pfizer, and UCB. Prof. Machado has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie, Abcuro, Eli Lilly, Galapagos/Alfasigma, Greywolf, Novartis, Orphazyme, Pfizer, and UCB.
Dana P. Ascherman, MD	Dr. Ascherman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boehringer Ingelheim. The institution of Dr. Ascherman has received research support from Boehringer Ingelheim. The institution of Dr. Ascherman has received research support from Teva. The institution of Dr. Ascherman has received research support from Mallinckrodt. The institution of Dr. Ascherman has received research support from Alpine. The institution of Dr. Ascherman has received research support from NIH.
Olivier Benveniste, MD, PhD (Hôpital Pitié-Salpêtrière)	No disclosure on file
Said R. Beydoun, MD, FAAN (University of Southern California Healthcare Consultation Center 2)	Dr. Beydoun has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Janssen. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for CSL. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Argenx. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Beydoun has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Alnylam. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Alexion. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for CSL. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Takeda. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for AstraZeneca. Dr. Beydoun has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Argenx. Dr. Beydoun has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Janssen. The institution of Dr. Beydoun has received research support from Abcuro. The institution of Dr. Beydoun has received research support from Sean Healy & AMG Center for ALS. The institution of Dr. Beydoun has received research support from Regeneron. The institution of Dr. Beydoun has received research support from RemeGen. The institution of Dr. Beydoun has received research support from Sanofi. The institution of Dr. Beydoun has received research support from Novartis.
Thomas Brannagan III, MD, FAAN (Columbia University)	Dr. Brannagan has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Intellia. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Astra Zenica. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Annexon. The institution of Dr. Brannagan has received research support from Alnylam. The institution of Dr. Brannagan has received research support from Abcuro. The institution of Dr. Brannagan has received research support from Ionis. The institution of Dr. Brannagan has received research support from Vertex. The institution of Dr. Brannagan has received research support from NMD Pharma.
Lisa Christopher-Stine, MD, MPH (Johns Hopkins University School of Medicine)	No disclosure on file
Michael P. Collins, MD (Medical College of WI-Dept. of Neurology)	Dr. Collins has nothing to disclose.
Jan L. De Bleecker, MD, PhD, FAAN (Neurology/University Hospital)	Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ArgNX. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving as a Consultant for Biogen. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Johnson and Johnson. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. The institution of Dr. De Bleecker has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for CSL Behring. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen pharmaceuticals. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amicus. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abcuro.
Mazen M. Dimachkie, MD, FAAN (University of Kansas Medical Center)	Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Octapharma. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ArgenX. Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for Catalyst. Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for Takeda. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medlink. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CSL Behring. Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for Astellas. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Janssen. Dr. Dimachkie has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Dianthus. Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for TACT / Treat NMD. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cabaletta Bio. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Clinical Neurological Society of America, Inc . Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for Ig Society, Inc. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abcuro. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amicus. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Horizon/Immunovant. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ipsen. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nuvig. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ��ɫ�� (AAN). Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM). Dr. Dimachkie has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Annexon Biosciences. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AstraZeneca. Dr. Dimachkie has received personal compensation in the range of $0-$499 for serving as a Consultant for Candid Therapeutics. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Creyon Bio, Inc.. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nuvig Therapeutics. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB Biopharma. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vertex Pharmaceuticals. Dr. Dimachkie has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Fortrea. Dr. Dimachkie has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kriya Therapeutics. The institution of Dr. Dimachkie has received research support from NIH. The institution of Dr. Dimachkie has received research support from The Myositis Association. The institution of Dr. Dimachkie has received research support from Biosensics. Dr. Dimachkie has received intellectual property interests from a discovery or technology relating to health care. Dr. Dimachkie has received intellectual property interests from a discovery or technology relating to health care. Dr. Dimachkie has received intellectual property interests from a discovery or technology relating to health care. Dr. Dimachkie has received publishing royalties from a publication relating to health care. Dr. Dimachkie has received publishing royalties from a publication relating to health care.
Stacy E. Dixon, MD (University of Colorado)	The institution of Dr. Dixon has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. The institution of Dr. Dixon has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring. The institution of Dr. Dixon has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Dixon has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Dixon has received publishing royalties from a publication relating to health care.
David R. Fernandez, MD, PhD	Dr. Fernandez has nothing to disclose.
Miriam L. Freimer, MD, FAAN (The Ohio State University)	Dr. Freimer has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for argenx. Dr. Freimer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for alexion. Dr. Freimer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for J and J. Dr. Freimer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. The institution of Dr. Freimer has received research support from Alnylum. The institution of Dr. Freimer has received research support from UCB. The institution of Dr. Freimer has received research support from NIH. The institution of Dr. Freimer has received research support from Janssen. Dr. Freimer has received research support from Avidity. Dr. Freimer has received research support from Fulcrum. The institution of Dr. Freimer has received research support from Dept of defense. The institution of an immediate family member of Dr. Freimer has received research support from Abcurro. Dr. Freimer has received personal compensation in the range of $10,000-$49,999 for serving as a presentations/teaching with UCB.
Christopher D. Geiger, MD, FAAN (University Hospitals-Cleveland Medical Center)	Dr. Geiger has nothing to disclose.
Paloma Gonzalez-Perez, MD, PhD (Massachusetts General Hospital)	An immediate family member of Dr. Gonzalez-Perez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Texas Alzheimer's Research and Care Consortium. Dr. Gonzalez-Perez has received personal compensation in the range of $0-$499 for serving as a Member of Neuromuscular CME Committee with ABPN.
Neelam Goyal, MD, FAAN (Stanford University)	Dr. Goyal has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Argenx. Dr. Goyal has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Goyal has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Janssen. Dr. Goyal has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. The institution of Dr. Goyal has received research support from Argenx.
Kelly G. Gwathmey, MD (VCU Neuroscience, Orthopedic, and Wellness)	Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion Pharmaceuticals. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Argenx. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Argenx. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Strongbridge. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Gwathmey has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion Pharmaceuticals. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cabaletta. Dr. Gwathmey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion Pharmaceuticals.
Daragh Heitzman, MD, FAAN (Texas Neurology)	The institution of Dr. Heitzman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amylyx Pharmaceuticals. The institution of Dr. Heitzman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. The institution of Dr. Heitzman has received personal compensation in the range of $0-$499 for serving as a Consultant for MMIT . The institution of Dr. Heitzman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Amylyx Pharmaceuticals. The institution of Dr. Heitzman has received research support from Muscular Dystrophy Association. The institution of Dr. Heitzman has received research support from Amylyx Pharmaceuticals. The institution of Dr. Heitzman has received research support from Anelixis. The institution of Dr. Heitzman has received research support from Cytokinetics. The institution of Dr. Heitzman has received research support from Mitsubishi - MT. The institution of Dr. Heitzman has received research support from Healey Platform Trial.
Robert Henderson, MBBS (Royal Brisbane Hospital)	Dr. Henderson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Henderson has received publishing royalties from a publication relating to health care.
Lisa Hobson-Webb, MD, FAAN (Duke University Medical Center)	Dr. Hobson-Webb has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NMD Therapeutics. Dr. Hobson-Webb has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion . The institution of Dr. Hobson-Webb has received research support from Abcuro. The institution of Dr. Hobson-Webb has received research support from Avidity. Dr. Hobson-Webb has received personal compensation in the range of $500-$4,999 for serving as a ��ɫ��al Talk - not speaker bureau with Takeda. Dr. Hobson-Webb has received personal compensation in the range of $500-$4,999 for serving as a ��ɫ��al Talk - not speaker bureau with CSL Behring.
Yessar M. Hussain, MD (Austin Neuromuscular Center)	The institution of Dr. Hussain has received research support from Alnylam Pharma.
Lawrence Korngut, MD	Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe. Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche.
Christina L. Liang, MBBS, FRACP (Royal North Shore Hospital)	Dr. Liang has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen Australia Pty Ltd. Dr. Liang has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Products Pty Ltd. Dr. Liang has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen Australia Pty Ltd. Dr. Liang has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche Products Pty Ltd. The institution of Dr. Liang has received research support from NHMRC Medical Research Future Fund. The institution of Dr. Liang has received research support from Abcuro for reimbursement of studies' costs.
James B. Lilleker, MBChB (University of Manchester)	Mr. Lilleker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Mr. Lilleker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Dyne. Mr. Lilleker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abcuro.
Thomas E. Lloyd, MD, PhD (Baylor College of Medicine)	Dr. Lloyd has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier.
Payam Mohassel, MD (Johns Hopkins University)	Dr. Mohassel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Leal Therapeutics LLC. Dr. Mohassel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Dr. Mohassel has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Carr Maloney PC. Dr. Mohassel has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for SARNO DA COSTA D'ANIELLO MACERI WEBB ATTORNEYS AT LAW. The institution of Dr. Mohassel has received research support from NIH-- K22. The institution of Dr. Mohassel has received research support from DoD. The institution of Dr. Mohassel has received research support from Million Dollar Bike Ride UPenn. The institution of Dr. Mohassel has received research support from NIH-- R01. The institution of Dr. Mohassel has received research support from Packard Center for ALS Research. The institution of Dr. Mohassel has received research support from Live Like Lou Foundation. The institution of Dr. Mohassel has received research support from Maryland Stem Cell Research Fund. Dr. Mohassel has received personal compensation in the range of $0-$499 for serving as a CME Honorarium as Writer with MedLink Neurology. Dr. Mohassel has a non-compensated relationship as a Scientific Advisory Board Member with RYR1 Foundation that is relevant to AAN interests or activities. Dr. Mohassel has a non-compensated relationship as a Editorial Board member with Neuromuscular Disorders (Journal) that is relevant to AAN interests or activities. Dr. Mohassel has a non-compensated relationship as a Editorial Board member with Journal of Neuromuscular Diseases that is relevant to AAN interests or activities.
Elie Naddaf, MD (Mayo Clinic)	Dr. Naddaf has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Expert Connect. Dr. Naddaf has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Klick, Inc. Dr. Naddaf has received personal compensation in the range of $500-$4,999 for serving as a Consultant for WebMD. Dr. Naddaf has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson and Johnson. Dr. Naddaf has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Arcellx. The institution of Dr. Naddaf has received research support from NIAMS. The institution of Dr. Naddaf has received research support from Fulcrum therapeutics. The institution of Dr. Naddaf has received research support from Abcuro. The institution of Dr. Naddaf has received research support from Cabaletta . The institution of Dr. Naddaf has received research support from Arcellx.
Merrilee Needham, MD	Dr. Needham has received personal compensation in the range of $500-$4,999 for serving as a Consultant for teva. Dr. Needham has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for abcuro. Dr. Needham has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for sanofi aventis.
Ezequiel A. Piccione, MD, FAAN (UNMC)	Dr. Piccione has nothing to disclose.
Colin Quinn, MD (University of Pennsylvania)	Dr. Quinn has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abcuro. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Voyager Therapeutics. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Catalyst Pharmaceuticals.
Laura K. Rosow, MD (UCSF Department of Neurology)	Dr. Rosow has nothing to disclose.
Bhaskar Roy, MD, FAAN (Yale University)	Dr. Roy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for argenx. Dr. Roy has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Roy has stock in Cabaletta bio. . Dr. Roy has stock in Pfizer. Dr. Roy has stock in CAVA. The institution of Dr. Roy has received research support from Abcuro Pharmaceuticals. The institution of Dr. Roy has received research support from Immunovant. The institution of Dr. Roy has received research support from argenx.
Tobias Ruck (Heinrich-Heine-University Düsseldorf, Department of Neurology)	No disclosure on file
Jens Schmidt, MD, FAAN (University Hospital Brandenburg Medical School / Immanuel Klinik Rüdersdorf)	Dr. Schmidt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CSL Behring and UCB. Dr. Schmidt has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring and LFB. Dr. Schmidt has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for CSL Behring. Dr. Schmidt has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB. The institution of Dr. Schmidt has received research support from Kezar, Novartis and AFM.
Arjun Seth, MD	Dr. Seth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Argenx. Dr. Seth has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB Pharma. Dr. Seth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Johnson and Johnson. Dr. Seth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Seth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi.
Jaimin S. Shah, MD (Mayo Clinic Florida)	Dr. Shah has stock in Lime Therapeutics. The institution of Dr. Shah has received research support from Argenx. The institution of Dr. Shah has received research support from Healey Center. The institution of Dr. Shah has received research support from Muscular Dystrophy Association. The institution of Dr. Shah has received research support from Center for Disease Control. The institution of Dr. Shah has received research support from National Institutes for Health.
Aziz I. Shaibani, MD, FAAN (Houston Neurocare, PA)	Dr. Shaibani has nothing to disclose.
Perry Shieh, MD, PhD, FAAN (UCLA)	Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sarepta. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Argenx. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for CSL Behring. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Grifols. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Alexion. Dr. Shieh has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Biogen. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Genentech. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Argenx. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Catalyst.
Zachary Simmons, MD, FAAN (Penn State Hershey Med Center)	Dr. Simmons has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amylyx. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Clene. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Insmed. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corcept. The institution of Dr. Simmons has received personal compensation in the range of $50,000-$99,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of Dr. Simmons has received research support from MGH. The institution of Dr. Simmons has received research support from Clene. The institution of Dr. Simmons has received research support from NIH via MGH. The institution of Dr. Simmons has received research support from Aburo. The institution of Dr. Simmons has received research support from NIH subaward via Univ of Pennsylvania.
Kumaraswamy Sivakumar, MD, MRCP	Dr. Sivakumar has nothing to disclose.
Leo H. Wang, MD, PhD, FAAN (University of Washington)	Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AskBio. Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Fulcrum Therapeutics. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe. Dr. Wang has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Argenx. Dr. Wang has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Avidity. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lupin. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sarepta. Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Scholar Rock. The institution of Dr. Wang has received research support from National Institute of Health. Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with US Government.
Conrad Weihl, MD, PhD (Washington University in St. Louis)	Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sarepta. Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Casma therapeutics. Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abata. Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. Dr. Weihl has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acceleron. Dr. Weihl has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Wilson Elser Moskowitz Edelman & Dicker LLP.
H Jeffrey Wilkins, MD	Dr. Wilkins has received personal compensation for serving as an employee of Abcuro.
Anthony A. Amato, MD, FAAN (Brigham and Women's Hospital)	Dr. Amato has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Johnson & Johnson. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for argenx. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abcuro. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Caballeta. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Takeda. Dr. Amato has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Viridian Therapeutics. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medpace. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Amato has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. Dr. Amato has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for legal firms. The institution of Dr. Amato has received research support from NIH. Dr. Amato has received publishing royalties from a publication relating to health care.

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