好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Eye-tracking as a Digital Biomarker of Processing Speed and Mobility in Multiple Sclerosis
Multiple Sclerosis
S8 - Multiple Sclerosis: Imaging, Biomarkers, and Environmental Exposures (5:06 PM-5:18 PM)
009
To investigate the associations between eye-tracking metrics and walking performance in patients with Multiple Sclerosis (MS), exploring oculomotor behavior as a potential digital biomarker of processing speed and mobility.
The Timed 25-Foot Walk (T25FW) is a quantitative test of mobility and leg function widely used in MS. Efficient walking requires rapid visuomotor integration, attentional shifting, and cerebellar timing, which are functions reflected in eye-movement control. Eye-tracking may reveal subtle neurophysiologic correlates of gait and processing speed. We aim to examine associations between eye-tracking metrics and walking performance in patients with MS, exploring oculomotor parameters as potential digital biomarkers of processing speed and mobility.

We evaluated 104 MS patients (mean age 37.3 ± 10.4 years; 74% female) using the Neurolign Dx100 eye-tracking system, assessing fixation, saccadic, pursuit, and vergence tasks. Spearman correlations were calculated between 65 eye-tracking variables and T25FW times (forward, backward, and mean). Lower T25FW times indicate faster walking.

Fixation Light parameters (on PSPV and ASPV, across horizontal and vertical gaze) correlated positively with slower T25FW performance (ρ = 0.26–0.30, p < 0.01), suggesting that impaired fixation stability and longer visual latency accompany reduced gait speed. Vergence Pursuit metrics, including Saccadic Component and Far Lag Asymmetry showed negative correlations with T25FW mean (ρ ≈ –0.21 to –0.24, p = 0.02–0.04), indicating that better binocular coordination are related to  faster ambulation. These associations were consistent across walking directions.
In MS, poorer fixation and vergence control were linked to slower T25FW performance, underscoring shared frontocerebellar mechanisms underlying ocular and motor coordination. Eye-tracking may serve as an objective, scalable digital biomarker of processing speed and functional mobility in MS.
Authors/Disclosures
Diogo Haddad Santos, MD (Moema)
PRESENTER 		Dr. Haddad Santos has nothing to disclose.
Dagoberto Callegaro, PhD No disclosure on file
Carolina B. Moura, MD (Hospital Universitário Antonio Pedro) Dr. Moura has nothing to disclose.
Sydni Martinez, PharmD Miss Martinez has nothing to disclose.
Rafael P. Castello dias Carneiro, dr No disclosure on file
Amanda C. Rodrigues, MS Miss Rodrigues has nothing to disclose.
Caio Goes (Faculdade de Ciências Médicas da Santa Casa de São Paulo) No disclosure on file
Alex Kinderman (Neurolign USA LLC - Neurolign) No disclosure on file
Renato Anghinah, MD, FAAN (University of Sao Paulo) Dr. Anghinah has nothing to disclose.