Abstract Details

Title Efficacy of Probiotics Supplementations for Management of Migraine: A Systematic Review and Meta-analysis.

Topic Headache

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 15-016

Objective This systematic review and meta-analysis aim to investigate the role of probiotics in migraine acute management and prevention in adults and children.

Background Migraine is as returning headaches with throbbing pain. Gut-brain axis integrity was suggested to play a role in disease pathogenesis. Probiotics were found to play a role in modulating this axis.

Design/Methods We searched [PubMed, Web of Science, Cochrane, and Scopus] till August 26, 2024, to identify articles on probiotics and migraine. Our eligibility criteria included clinical trials in which all age groups with migraine received probiotics, with separate analysis for the two age groups. Independent data extraction and risk of bias were performed. Meta-analysis was conducted using RevMan software v5.4.1 and R (v4.3.1).

Results We included nine clinical trials [n = 645 patients]. Probiotics significantly reduced migraine frequency in adult population [patients 192, MD: -1.60, 95% CI [-2.61, -0.59], P = 0.002, I-square = 84%] but not in children [patients 121, MD: 0.61, 95% CI [-2.01, 3.22], P = 0.65, I-square = 0%]. Severity also was reduced [patients 192, MD: -0.94, 95% CI [-1.84, -0.05], P = 0.04, I-square = 87%] with significant heterogeneity compared to placebo. It didn’t show a significant effect compared to placebo in duration [patients 192, MD: -2.21, 95% CI [-5.93, 1.51], P = 0.24, I-square = 80%] and level of CRP [patients 245, MD: -0.17, 95% CI [-0.44, 0.09], P = 0.20, I-square = 47%].

Conclusions We concluded that Probiotics may have a therapeutic benefit on migraine prophylaxis, evidenced by reduced frequency and severity. However, these findings are limited by the lack of significance of the rest of outcomes and the heterogeneity between studies. Future research is needed to confirm these results.

Authors/Disclosures
Khaled M. Mohamed, MD PRESENTER	Dr. Mohamed has nothing to disclose.
Dalia Kamal Ewis, MD	Miss Ewis has nothing to disclose.
Abdullah H. Almarfadi II (Faculte de medecine)	Mr. Almarfadi has nothing to disclose.
Omar K. Abdelsalam	Dr. Abdelsalam has nothing to disclose.
Mohammed Ali, MBBS	Dr. Ali has nothing to disclose.
Abdallah Abunamoos	Dr. Abunamoos has nothing to disclose.
Mohamed Mamdouh	Mr. Mamdouh has nothing to disclose.
Moaz E. Abouelmagd, MD	Dr. Abouelmagd has nothing to disclose.
Yagna Jarajapu, PhD	Prof. Jarajapu has nothing to disclose.

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