Abstract Details

Title Automated Image Guided Programming Algorithm Supports Clinicians during DBS Programming for Parkinson's Disease Patients

Topic Movement Disorders

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 17-015

Objective The clinical utility of an automated image-guided programming (aIGP) algorithm for optimizing deep brain stimulation (DBS) settings in patients with Parkinson’s disease is analyzed, and its performance against standard-of-care (SoC) programming is assessed.

Background As a process that can be time-consuming and burdensome for patients, DBS programming traditionally relies on iterative, clinician-led adjustments to balance therapeutic benefit and side effects. Recent advances in imaging and computational modeling have enabled algorithms that rapidly generate anatomically-informed stimulation settings. Automated image-guided programming can use patient-specific imaging to position a stimulation field model (SFM) within seconds, in turn targeting desired regions while minimizing spread to non-target areas.

Design/Methods To date, this prospective, multicenter, double-blinded crossover study has enrolled 15 PD patients with bilateral STN or GPi DBS systems. Participants were evaluated acutely and chronically under both SoC and aIGP-guided programming. Motor outcomes were assessed using MDS-UPDRS III (meds off/on), and chronic efficacy was evaluated via motor diaries. Clinicians could optimize aIGP-suggested settings, and changes were quantified using similarity metrics.

Results Initial aIGP DBS-on settings improved motor scores by 39% (meds-off) and 54% (meds-on) versus DBS-off (p<0.0001), with no significant difference from optimized SoC programming (p=0.44 and p=0.33, respectively). Chronic assessments showed aIGP-guided programs yielded 25 minutes/day more “ON” time and 58 minutes/day less “ON with dyskinesias” compared to SoC, though group-level differences were not statistically significant. Clinician-optimized aIGP settings remained largely unchanged. Additional data collected in the interim will be reported.

Conclusions Automated image-guided programming provides rapid, anatomically guided programming that achieves motor outcomes comparable to traditional methods. Its ability to streamline DBS optimization may reduce clinical burden and enhance personalization, supporting its integration into routine neuromodulation workflows.

Authors/Disclosures
Rajat Shivacharan PRESENTER	Dr. Shivacharan has received personal compensation for serving as an employee of Boston Scientific.
Jason L. Aldred, MD, FAAN (Selkirk Neurology)	Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Aldred has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Allergan . Dr. Aldred has received personal compensation in the range of $0-$499 for serving as a Consultant for Quadralynx. Dr. Aldred has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. Dr. Aldred has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Abbvie. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Acorda. Dr. Aldred has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Allergan. Dr. Aldred has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Boston Scientific. Dr. Aldred has received personal compensation in the range of $100,000-$499,999 for serving on a Speakers Bureau for TEVA. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medtronic. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for US World Meds. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Aldred has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Sunovion. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal. Dr. Aldred has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Aldred has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Arete Neuroscience, PLLC. The institution of Dr. Aldred has received research support from Biogen . The institution of Dr. Aldred has received research support from Abbvie. The institution of Dr. Aldred has received research support from Merz. The institution of Dr. Aldred has received research support from AstraZeneca. The institution of Dr. Aldred has received research support from Neurocrine. The institution of Dr. Aldred has received research support from Aptinyx. The institution of Dr. Aldred has received research support from Cerevance. The institution of Dr. Aldred has received research support from Boston Scientific . The institution of Dr. Aldred has received research support from Parkinson Foundation . The institution of Dr. Aldred has received research support from Roche. The institution of Dr. Aldred has received research support from Sage Therapeutics. The institution of Dr. Aldred has received research support from Annovis. The institution of Dr. Aldred has received research support from Biovie. The institution of Dr. Aldred has received research support from NeuroDerm. The institution of Dr. Aldred has received research support from PhotoPharma. The institution of Dr. Aldred has received research support from Lilly.
Corneliu C. Luca, MD (University of Miami)	Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boston Scientific. Dr. Luca has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Signant Health. Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott.
Adolfo Ramirez Zamora, MD (University of Louisville)	Dr. Ramirez Zamora has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Medtronic. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevel therapeutics. Dr. Ramirez Zamora has received personal compensation in the range of $0-$499 for serving as a Consultant for NeuroPacs. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Iota Inc. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Maplight. Dr. Ramirez Zamora has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. The institution of Dr. Ramirez Zamora has received research support from Parkinsons Foundation.
Joshua Wong, MD (University of Florida College of Medicine - Neurology)	The institution of Dr. Wong has received research support from NIH.
Kristy Wessels, PA (Sellkirk Neurology)	An immediate family member of Mrs. Wessels has received personal compensation in the range of $500,000-$999,999 for serving as a Consultant for Eli Lilly . An immediate family member of Mrs. Wessels has stock in Eli Lilly .
Taylor Peabody, MD	Dr. Peabody has nothing to disclose.
Ben Reese (Boston Scientific)	Ben Reese has received personal compensation for serving as an employee of Boston Scientific. Ben Reese has stock in Boston Scientific.
Beth E. Farber Petrey, BS	Mrs. Farber Petrey has received personal compensation for serving as an employee of Boston Scientific. Mrs. Farber Petrey has stock in Boston Scientific.
Richard Mustakos	Mr. Mustakos has received personal compensation for serving as an employee of Boston Scientific. Mr. Mustakos has stock in Boston Scientific. Mr. Mustakos has received intellectual property interests from a discovery or technology relating to health care.
Soroush Niketeghad, PhD	Dr. Niketeghad has received personal compensation for serving as an employee of Boston Scientific.
Mahsa Malekmohammadi, PhD	Dr. Malekmohammadi has received personal compensation for serving as an employee of Boston Scientific Neuromodulation.

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