Abstract Details

Title The Role of Dementia Risk Factors in Cognitive Outcomes in TBI

Topic Neuro Trauma and Critical Care

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 18-008

Objective To examine the relationship between dementia risk factors on cognitive outcomes in TBI clinic patients.

Background Traumatic brain injury (TBI) can lead to cognitive impairment and is a risk factor for dementia, yet predictors of post-injury cognitive outcomes remain poorly understood. Montreal Cognitive Assessment (MoCA) is a screening tool that evaluates cognitive impairment across cognitive domains. Factors like multiple lifetime TBI’s, poor brain health, lack of insurance and education are risk factors for Alzheimer’s dementia, but their role in cognitive impairment post-mTBI is unclear. We hypothesize that the same risk factors in dementia are associated with lower MoCA performance post-TBI.

Design/Methods Retrospective cohort study of TBI seen in a clinic setting [UCI-NTBIC database (9/2022–6/2025)]. Inclusion criteria: patients ≥18 years old, TBI per American College of Rehabilitation (ACRM) Criteria. Exclusion: premorbid dementia, unable to complete MoCA secondary to disability. Primary exposures: McCance Brain Care Score as brain health measure (21-point questionnaire), self-reported number of TBI, Insurance Status Scale, Level of ��ɫ�� Scale. Primary outcome: MoCA score, with ≥ 26 considered within normal cognitive range. Descriptive statistics, multivariable logistic regression, Spearman correlation, and beta coefficient analyses were performed.

Results Among the 99 patients studied (mean age 47, 51% male, 76.5% mild TBI) no risk factor independently predicted poor MoCA outcome on regression. However, insurance coverage (β =1.67, p =0.0256), level of education (β = 1.08, 0.050), and McCance Brain Care Score (β = 0.450, p = 0.0435) were each significantly associated with MoCA scores.

Conclusions

Our exploratory findings suggest that greater insurance coverage, higher educational attainment, and higher braincare scores are associated with better cognitive outcomes post-TBI. Future work will assess how these factors influence cognitive trajectories over time in longitudinal follow-up.

Authors/Disclosures
Amanda Fang, Undergraduate student PRESENTER	Miss Fang has nothing to disclose.
Evelyn Zepeda	Evelyn Zepeda has nothing to disclose.
Asia Walter	Miss Walter has nothing to disclose.
Stephania B. Tovar Vargas, MPH	Ms. Tovar Vargas has nothing to disclose.
Maral Sakayan, MD (UCI Department of Neurology)	Dr. Sakayan has nothing to disclose.
Maria Thereza Paulino	Miss Paulino has nothing to disclose.
Alexis Conrad (Neurology Traumatic Brain Injury & Concussion (NTBIC) Program, Department of Neurology, University of California, Irvine, Orange, CA)	No disclosure on file
Arunima Kapoor	Ms. Kapoor has nothing to disclose.
Danh V. Nguyen, PhD	Prof. Nguyen has nothing to disclose.
S. Ahmad Sajjadi, MD, PhD, MRCP, FAAN (University of California, Irvine)	Dr. Sajjadi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GUIDEPOINT. Dr. Sajjadi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Research and Therapy. The institution of Dr. Sajjadi has received research support from NIH.
Mark Mapstone, PhD (University of California, Irvine)	Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Brain Neurotherapy Bio, Inc. Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon, Inc. Dr. Mapstone has received intellectual property interests from a discovery or technology relating to health care.
Michael Lopez, PhD	Michael Lopez has nothing to disclose.
Bernadette Boden-Albala, DrPH (University California Irvine)	Ms. Boden-Albala has received research support from NIH.
Patrick M. Chen, MD (UC Irvine Medical Center)	Dr. Chen has nothing to disclose.

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