Abstract Details

Title The Silent Surge: Two Decades of Rising Multiple Sclerosis Burden in the United States (1990–2023) — Insights from the Global Burden of Disease Study

Topic Global Health and Neuroepidemiology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 20-005

Objective To evaluate long-term trends in MS prevalence, disability-adjusted life years (DALYs), and mortality in the U.S. from 1990 to 2023, stratified by age and sex.

Background Despite therapeutic breakthroughs, the real-world burden of multiple sclerosis (MS) in the United States remains poorly characterized. The Global Burden of Disease (GBD) 2023 dataset provides a comprehensive opportunity to reassess national trends in MS morbidity and mortality over the past three decades.

Design/Methods Data on MS were extracted from the GBD 2023 database. Age-standardized rates (ASR) per 100,000 population for prevalence, DALYs, and deaths were analyzed. Temporal changes were quantified using percentage change and average annual percent change (AAPC) derived from Joinpoint regression.

Results Between 1990 and 2023, U.S. MS prevalence increased by 61.3%, from 94.8 to 152.9 per 100,000, while MS-related deaths rose from 0.91 to 1.42 per 100,000 (AAPC +1.2%/year; p<0.001). Total DALYs increased from 88,210 to 127,640, reflecting a growing disability burden despite improved survival. Women consistently accounted for nearly threefold higher rates than men (ASR 218.6 vs 74.5 in 2023). The steepest rise in prevalence occurred among adults aged 45–64 years.

Conclusions The U.S. continues to experience a rising MS burden despite therapeutic advances. Increasing prevalence and disability, particularly among middle-aged women, underscore the need to expand preventive, rehabilitative, and long-term care strategies beyond pharmacologic management. These findings reflect a silent but significant shift in the nation’s neurological disease landscape.

Authors/Disclosures
Aishwar Dixit (Baba Raghav Das Medical College, Gorakhpur) PRESENTER	No disclosure on file
Sweta Sahu	Dr. Sahu has nothing to disclose.
Aditya Jain, MBBS	Dr. Jain has nothing to disclose.
Aditi Narsinghpura, MBBS	Dr. Narsinghpura has nothing to disclose.
Abhigna Mallepally, MBBS	Abhigna Mallepally, MBBS has nothing to disclose.
SANKRANTHI SARATH CHANDRA, MBBS	Dr. CHANDRA has nothing to disclose.

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