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Abstract Details

Impact of Obesity on Hospitalization Outcomes Among Patients Admitted for Multiple Sclerosis Exacerbations: An Analysis of the National Inpatient Sample Database
Multiple Sclerosis
P1 - Poster Session 1 (8:00 AM-9:00 AM)
20-012
To study the impact of obesity on hospitalisation outcomes among patients admitted for multiple sclerosis exacerbations by utilising the national inpatient sample database from 2016 to 2022.

Several studies have demonstrated a link between multiple sclerosis (MS) and obesity. However, the data on the impact of obesity on outcomes of multiple sclerosis exacerbations is limited.

We used the ICD-10 codes E66 for obesity and Z468 for BMI codings; G35 for multiple sclerosis. The outcomes of interest were length of stay (LOS), in-hospital mortality, discharge disposition, and total charges. All analyses used survey-weighted logistic regression to account for strata and discharge weights.  We used multivariate regression models to adjust for confounders such as age, sex, race/ethnicity, comorbidity index, and APR-DRG severity/risk. The p-value was kept significant at ≤ 0.05 with a 95% confidence interval.
We identified 158,109.96 MS exacerbation admissions (non-obese 128,060.00; obese 30,049.99; obesity share 19.00%). Obese patients were younger (mean age 44.81 [95% CI 44.46–45.16] vs 46.59 [46.39–46.79] years), and predominantly female (79.4% [78.31–80.41] vs 69.6% [68.98–70.14]). Obesity was associated with a longer length of stay in obese patients (4.82 ± 0.09 days) compared with non-obese (4.61 ± 0.05 days; p=0.02). In-hospital mortality difference was insignificant, albeit numerically lower in obese (0.17%, 95% CI 0.09–0.32) than in non-obese patients (0.24%, 95% CI 0.19–0.31; p=0.09). Mean total hospital charges were marginally higher in obese MS exacerbation admissions ($67,890 ± 1,530) than in non-obese ($65,440 ± 1,280; p=0.04). Disposition differed among the groups: discharge to home occurred in 59.9% of obese vs. 59.3% of non-obese patients, while transfer to skilled nursing/ rehabilitation facilities was 18.9% for obese and 20.0% for non-obese.
Obese patients had higher comorbidity burden and slightly longer LOS, but comparable mortality and similar discharge patterns. Obese patients were younger and predominantly female.
Authors/Disclosures
Muhammad Sohaib, MBBS
PRESENTER 		Mr. Sohaib has nothing to disclose.
Hafiz M. Maaz (Quaid-e-Azam Medical College, Bahawalpur Pakistan) Mr. Maaz has nothing to disclose.
Muhammad Ahmed, MD (Medical College of Georgia, Augusta University) Dr. Ahmed has nothing to disclose.
Haris Kamal, MD (University of Texas At Houston) Dr. Kamal has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Microvention .
Muhammad Tayyab Muzaffar Chaychi, MD Muhammad Tayyab Muzaffar Chaychi, MD has nothing to disclose.