Fifty patients were included (mean age 62.2 years); 54% were male and 46% female. Autoimmune disorders—mainly antiphospholipid syndrome, systemic lupus erythematosus, and thyroid dysfunction—were found in 16% of cases. The most frequently affected sinuses were the rectus (4%) and cavernous (4%), with occasional superior petrosal involvement (2%). Compared with global reports, where CVT accounts for 0.5–1% of strokes and typically affects younger women, our findings indicate a higher age at presentation, balanced sex distribution, and similar autoimmune association. This series provides region-specific data that contribute to filling existing epidemiologic gaps in Latin America.