Abstract Details

Title Autoimmune Cerebellitis with Concurrent Anti-Tr/DNER and Anti-mGLUR1 Antibodies

Topic Autoimmune Neurology

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 1-011

Objective To describe the first known case of autoimmune cerebellitis with concurrent anti-Tr/DNER and anti-mGluR1 antibodies and highlight diagnostic and therapeutic implications.

Background Anti-Tr/DNER and anti-mGluR1 antibodies both target Purkinje cells but differ in oncologic associations and treatment responsiveness. Dual positivity has not been previously reported.

Design/Methods Case report of a 45-year-old woman presenting with subacute vertigo, oscillopsia, and gait ataxia. MRI was normal, CSF showed lymphocytic pleocytosis with CSF-specific oligoclonal bands, and paraneoplastic/encephalitis panels revealed high-titer anti-Tr/DNER and anti-mGluR1 antibodies in both serum and CSF. Oncologic evaluation was negative.

Results Plasma exchange and symptomatic therapy yielded limited improvement. Four months after onset, rituximab induced rapid functional recovery, with restored independent ambulation and sustained stability at 3-month follow-up.

Conclusions This case expands the autoimmune cerebellitis spectrum by demonstrating coexistence of a classic paraneoplastic antibody (anti-Tr/DNER) and a potentially reversible cell-surface antibody (anti-mGluR1). It underscores the importance of comprehensive antibody testing to guide malignancy screening and early escalation to B-cell–directed therapy when first-line treatments fail.

Authors/Disclosures
Floyd Silva, MD PRESENTER	Dr. Silva has nothing to disclose.
Lea Saab	Miss Saab has nothing to disclose.
Isaac Smith, DO, MS	Dr. Smith has nothing to disclose.
Melanie Li, MD	Dr. Li has nothing to disclose.
Lauren Brandes, MD	Dr. Brandes has nothing to disclose.
Mihir Kakara, MD	Dr. Kakara has nothing to disclose.

��ɫ��

��ɫ��