Abstract Details

Title Functional Neurological Disorder in a Multidisciplinary Clinic: Demographic and Clinical Correlates

Topic Movement Disorders

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 16-008

Objective

To characterize the multimorbid presentation of functional neurological disorder (FND) and examine associations between patient characteristics and outcomes.

Background FND arises from network dysfunction rather than structural brain abnormalities.^1,2 Despite its prevalence, FND remains poorly understood and often stigmatized.^1-4 Patients may experience non-epileptic seizures or movement symptoms causing substantial distress and disability.^1,2,4 Few studies describe the multimorbid presentation of FND or associations between sociodemographic factors, clinical characteristics, and patient-reported attitudes and outcomes.

Design/Methods We established a multidisciplinary FND clinic integrating neurology, psychology, and physical therapy. Patients (n=49) completed questionnaires covering sociodemographic, medical and psychiatric history, and symptom domains. Questionnaire data and chart review were analyzed using descriptive statistics. Associations between clinical features and three continuous outcome measures, including diagnosis confidence, treatment confidence, and Clinical Global Impression-Severity (CGI-S) score, were evaluated with Pearson correlations, linear regression, and one-way ANOVA. Significance was set at p<0.05 (R v4.5.1).

Results Patients were predominantly women (69.4%), mean age of 55.4 years, white (79.6%), non-Hispanic (69.4%), married/partnered (57.4%), and college educated (63%). Mean symptom duration was 7.4 years, with averages of 3.8 primary concerns, 4.8 cognitive problems (range 0–10), and 13 physical problems (range 0–25). Common comorbidities included anxiety (76%), chronic pain (75%), depression (55%), headaches (53%), and poor sleep (41%). Nearly half (47%) reported abuse history. Functional dependence was prevalent, with 38% requiring assistance with instrumental activities of daily living (IADLs) and 25% requiring assistance with both activities of daily living (ADLs) and IADLs. CGI-S scores correlated with cognitive (r=0.32, p=0.03) and physical symptom burden (r=0.34, p=0.02), and ADL impairment (p<0.01). Diagnosis confidence correlated with physical symptom count (r=0.31, p=0.049). No associations were observed for marital status, abuse history, social support, depression, or anxiety.

Conclusions FND patients show high multimorbidity and functional impairment, underscoring the need for multidisciplinary, integrated care addressing neurological, psychological, and functional domains to improve outcomes.

Authors/Disclosures
Roshni D. Singh, MD PRESENTER	The institution of an immediate family member of Ms. Singh has received research support from Department of Veterans Affairs. The institution of an immediate family member of Ms. Singh has received research support from Pfizer Infependent Grants for Learning and Change. The institution of an immediate family member of Ms. Singh has received research support from National Institutes of Health. The institution of an immediate family member of Ms. Singh has received research support from Department of Defense. The institution of an immediate family member of Ms. Singh has received research support from Florida Department of Health Biomedical Research Foundation .
Minao Tang	Mr. Tang has nothing to disclose.
Jason H. Margolesky, MD, FAAN (University of Miami School of Medicine)	Dr. Margolesky has nothing to disclose.

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