Abstract Details

Title Prognostic Significance of Hyponatremia in Acute Stroke: A Systematic Review and Meta-analysis

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 4-012

Objective The aim of this study is to conduct a systematic review and meta-analysis to evaluate the association between hyponatremia and mortality in adult patients with acute ischemic or hemorrhagic stroke.

Background Hyponatremia is the most common electrolyte abnormality in stroke patients. Multiple studies reported that sodium abnormalities at the time of admission is linked to higher in-hospital mortality, poorer neurological status, and longer hospital stays.

Design/Methods This meta-analysis included retrospective and prospective cohort studies and cross-sectional studies. We searched medical databases including PubMed, Embase, and screened additional journals such as Cureus from 2010 to 2025 following PRISMA guidelines for systematic review and meta-analysis. Data analysis was performed using R software (version 4.5.1). Combined odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model to analyze the data. ChatGPT (GPT-5) was used to troubleshoot an error in R programming during data analysis. All AI-assisted outputs were reviewed and verified by the authors.

Results Six retrospective and two prospective observational cohorts, as well as one cross-sectional study, were analyzed. Our pooled analysis of 9 studies including 19,469 patients showed hyponatremia to be associated with worse outcomes. The random-effects model gave an odds ratio of 1.81 (95% CI: 1.31–2.51, p < 0.0003), indicating that stroke patients with low sodium have an 81% higher odds of mortality compared to patients with normal sodium levels. Heterogeneity was high (I² = 92.8%), suggesting variability between these studies. These findings highlight hyponatremia as a significant prognostic factor for mortality in acute stroke patients.

Conclusions Hyponatremia is associated with increased mortality in patients with ischemic or hemorrhagic stroke, reinforcing the importance of electrolyte monitoring and early intervention.

Authors/Disclosures
Sai Erambalur PRESENTER	Ms. Erambalur has nothing to disclose.
NagaVenkata Priya Sri Harshitha Somarouthu	Miss Somarouthu has nothing to disclose.
Onyeka Chukwuma, MD	Miss Chukwuma has nothing to disclose.

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