Abstract Details

Title A Novel Vessel Tortuosity Scale for the Analysis of Cerebral Aneurysm Formation and Rupture Risk

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-004

Objective This study aimed to develop and validate a quantitative vessel tortuosity scale to characterize cerebral vascular geometry and assess its relationship with aneurysm formation and rupture.

Background Nontraumatic subarachnoid hemorrhage is often due to a ruptured cerebral aneurysm (CA). Vessel tortuosity is associated with numerous vascular diseases. Recent data suggests that tortuosity may correlate with aneurysm formation and progression.

Design/Methods A well-established, elastase-mouse CA model was used to assess cerebral vessel tortuosity in correlation with CA formation/rupture in sham (n=13), 3.5mU (n=14), and 35 mU (n=20) elastase groups. Quantitative (tortuosity index) and qualitative (large and small vessel curvature) analysis were used to create an ordinal visual scale ranging from 1 (low tortuosity) to 4 (high tortuosity) to evaluate predictive capacity for vessel tortuosity level and CA formation and rupture.

Results Nearly all sham animals (92%) had little to no vessel tortuosity on the visual scale (median, IQR: 1, [1-2]), compared to 29% in the 3.5mU (2, [1.25-3]), and 21% in the 35mU (2, [2-3]) cohorts. Sham cohorts had zero animals with highly tortuous vessels while 3.5mU and 35mU cohorts had >35% of animals with significant visual tortuosity, p=0.003 and p<0.000, respectively. CA formation and rupture was significantly higher in the elastase groups compared to the sham group (p=0.002). Both the visual scale and tortuosity index significantly predicted CA formation (p<0.001) and rupture (p<0.000).

Conclusions A novel tortuosity scale is highly predictive of CA formation and rupture in vivo and may offer a novel measurement to better understand vessel stress in the natural history of CAs.

Authors/Disclosures
Naser Hamad, Medical Student PRESENTER	Mr. Hamad has nothing to disclose.
Maxon Knott (University of Miami Miller School of Medicine)	The institution of Maxon Knott has received research support from American Heart Assiciation.
Sailaja Sanikommu, MBBS (V.N.M Hopsital)	Dr. Sanikommu has nothing to disclose.
Pedro Bartkevitch Rodrigues, MD	Dr. Bartkevitch Rodrigues has nothing to disclose.
Jennifer S. Suon	Miss Suon has nothing to disclose.
Tiffany A. Eatz, MD (University of Miami Miller School of Medicine)	Dr. Eatz has nothing to disclose.
John W. Thompson, PhD	Dr. Thompson has nothing to disclose.
Robert Starke	Robert Starke has nothing to disclose.

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