Abstract Details

Title High Prevalence of Neurogenic Orthostatic Hypotension in Mexican Neurodegenerative Patients: A Pilot Cohort

Topic Autonomic Disorders

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 7-014

Objective To describe the prevalence of neurogenic orthostatic hypotension in Mexican patients with neurodegenerative diseases using standardized autonomic testing.

Background Neurogenic orthostatic hypotension (nOH) is a hallmark of autonomic failure in neurodegenerative diseases. It manifests as a non-motor symptom impacting motor progression and exacerbations. While synucleinopathies are well-studied for nOH alongside motor and cognitive features, data on autonomic dysfunction in other conditions, particularly in Mexico are unknown.

Design/Methods Between January 1 and September 1, 2025, we evaluated Mexican patients referred for new-onset nOH or with established neurodegenerative diagnoses who developed new nOH symptoms. Participants (n=20; 13 males, 7 females; mean age 69.5 years) were predominantly Hispanic (n=14) and from diverse regions, including Mexico State (n=7) and Mexico City (n=5). All underwent standardized autonomic function tests, including smell sense and cognitive evaluation.

Results A total of n=20 patients were included in our study. Diagnosis included: Pure autonomic failure (n=1, 5%), Parkinson disease (n=7, 35%), dementia with Lewy bodies (n=7, 35%), Huntington disease (n=2, 10%), and adult-onset leukodystrophy (n=3, 15%). Autonomic testing revealed early nOH in 10 (50%), late nOH in n=5 (25%), and supine hypertension in n=9 (45%). Delta heart rate/systolic blood pressure ratio (HR/SBP ratio) was 0.04 at 3 minutes and 0.21 at 10 minutes. Valsalva maneuver showed absent late phase II and phase IV overshoot in n=13 (65%). Mean hand and foot temperatures were 29.9°C and 29.0°C, respectively. Mean UPSIT and MoCA scores were 21 and 24, respectively. Mean post-void residual volume was 60 mL, with urinary retention in n=12 (60%).

Conclusions In this pilot cohort, nOH prevalence was 75% and neurogenic supine hypertension occurred in 45% of cases, with autonomic involvement across sporadic and genetic neurodegenerative diseases. These findings underscore the importance of autonomic evaluation in all patients with neurodegenerative diseases in Latin America otherwise the initial or final diagnosis.

Authors/Disclosures
Daniel Rebolledo, Jr., MD (Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán) PRESENTER	Dr. Rebolledo has nothing to disclose.
SANDRA Y. ROBLES BERNAL III	Miss ROBLES BERNAL has nothing to disclose.
Francisco A. Luna-Rangel, MD, BS	Dr. Luna-Rangel has nothing to disclose.
Benjamín Torres-Octavo, PhD	Dr. Torres-Octavo has nothing to disclose.
Karla Cardenas-Soto, PhD	Dr. Cardenas-Soto has nothing to disclose.
Daniel Martinez-Ramirez, MD (Oncare)	Dr. Martinez-Ramirez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB Mexico. Dr. Martinez-Ramirez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbott Mexico.

��ɫ��

��ɫ��