Abstract Details

Title Evaluating the Mortality Burden due to Motor Neuron Disease With Comorbid Respiratory Failure: A CDC WONDER Analysis of U.S. Population (1999–2023)

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 9-014

Objective Our goal is to investigate trends and implications that can aid in healthcare planning and patient assistance in the population of Motor Neuron diseases.

Background Motor neuron disease is a neurological disorder, a significant cause of neurological mortality in the United States, with a frequency of 3.8% in 2017 and a fatality rate of 0.8%. The clinical course and prognostic indicators are not extensively explored.

Design/Methods We retrieved mortality data from CDC WONDER database due to Motor Neuron Disease (ICD 10: G12.2) with comorbid respiratory failure (ICD 10: J96) from 1999-2023. We stratified Age-adjusted Mortality Rates across sex, race, ethnicity, census region, 2013- urbanization framework, and states. Temporal trends were assessed using Joinpoint regression (JPR) analysis, reporting Annual Percent Change (APCs) with 95% CIs (p < 0.05).

Results Between 1999 and 2023, 29,443 deaths were attributed to motor neuron disease (MND) with respiratory failure (AAMR = 1.52). Mortality was higher in males (56.4%) than females (43.6%) and predominantly affected White non-Hispanics (≈91%). Overall, mortality declined slightly until 2008, then rose modestly. Females showed a decline (1999–2005; APC = –2.11), while males declined (1999–2008; APC = –1.82) followed by a brief rise (2008–2011; APC = 4.05). Hispanics showed an upward trend (APC = 1.01), whereas Whites declined (1999–2006; APC = –1.75) then increased from 2006-2023 (APC = 0.59). Mortality rose in the Midwest (APC = 0.61), declined in the West (APC = –0.56), with the lowest AAMR in Louisiana (0.8) and highest in Vermont (2.4).

Conclusions From 1999–2023, MND mortality from respiratory failure was higher among men, non-Hispanic Whites, and residents of the Northeast, West, and small metro areas, reflecting biological, environmental, and healthcare disparities. Targeted surveillance, equitable care, and risk mitigation are vital to reduce mortality.

Authors/Disclosures
Sara Zakris PRESENTER	Mrs. Zakris has nothing to disclose.
Anfal Hamza	Mr. Hamza has nothing to disclose.
Arbaz Hassan, MBBS	Mr. Hassan has nothing to disclose.
Waqas Ahmad, MBBS	Mr. Ahmad has nothing to disclose.
Muhammad Umar Ejaz, MBBS	Dr. Ejaz has nothing to disclose.
Laiba Noor, MBBS	Miss Noor has nothing to disclose.
Archi Mehta	Ms. Mehta has nothing to disclose.
Sheraz Qasim, MBBS	Dr. Qasim has nothing to disclose.
Atif N. Malik, MD	Dr. Malik has nothing to disclose.
Talha Sajjad, MBBS	Dr. Sajjad has nothing to disclose.
Muhammad Saim, MBBS	Mr. Saim has nothing to disclose.
Hafiz Haseeb H. Ahsan, MBBS	Dr. Ahsan has nothing to disclose.
Faseeh Haider, MD, MBBS	Dr. Haider has nothing to disclose.

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