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Abstract Details

Brief Estimate of Seconds Test: A New Paradigm for Evaluation of Time Perception in Parkinson's Disease
Aging, Dementia, and Behavioral Neurology
P11 - Poster Session 11 (11:45 AM-12:45 PM)
13-008
To determine a standardized and validated measure of time perception in Parkinson's disease (PD) populations that may also be generalizable to patients with other neurologic disease
Evidence suggests patients with PD experience altered time perception (chronognosia/chronothesia) as part of neuropsychiatric decline. No standardized measure exists for assessing time perception in this population. This study evaluated the Brief Estimate of Seconds Test (BEST) in PD patients versus healthy controls (HC) and examined neuroanatomical correlates of BEST performance.
The BEST was administered to 28 PD patients and 91 HCs. PD patients underwent MRI and additional neuropsychological exam. Analyses included: normative HC values; matched PD-HC comparison; and regression analyses examining relationships between BEST performance and (i) MRI-based atrophy in a priori regions of interest relevant to PD pathology and time perception, (ii) performance on standard cognitive measures of processing speed, executive function, and memory.
BEST performance correlated with atrophy in regions associated with both time perception and PD pathology (r=0.38-0.42 for putamen volume, p<0.05; r=-0.38-0.47 for posterior cingulate volume, p<0.05). BEST showed weak or no correlation with standard cognitive measures of processing speed, attention, executive function, and memory (r=-0.42 for Stroop interference p<0.05; otherwise p’s>0.05).
BEST performance correlates with atrophy in brain regions associated with time perception and PD pathology, supporting its validity as a standardized measure for assessing time perception in neurologic populations. The lack of correlation with standard cognitive measures suggests chronognosia/chronothesia may represent a distinct neurocognitive construct not adequately captured by existing clinical assessments. Time perception evaluation is underutilized but could meaningfully inform differential diagnosis, treatment monitoring, and functional assessment in neuropsychiatric conditions.
Authors/Disclosures
Hannah Branstetter, MD (Vanderbilt University Medical Center)
PRESENTER 		Dr. Branstetter has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for McGraw-Hill 好色先生 Inc. Dr. Branstetter has received publishing royalties from a publication relating to health care.
Talia Watras, MD (Vanderbilt University Medical Center) Dr. Watras has nothing to disclose.
Maeve Curtin Miss Curtin has nothing to disclose.
Kilian Hett, PhD Dr. Hett has nothing to disclose.
Hakmook Kang Hakmook Kang has nothing to disclose.
Fangxi Xu, MS Ms. Xu has nothing to disclose.
Daniel O. Claassen, MD, FAAN (Vanderbilt University Medical Center) Dr. Claassen has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Alterity. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Dr. Claassen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AskBio. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for University of Michigan. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cognition Therapeutics . Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amylyx. The institution of Dr. Claassen has received research support from NIH. The institution of Dr. Claassen has received research support from CHDI. The institution of Dr. Claassen has received research support from HDSA. The institution of Dr. Claassen has received research support from Department of Defense. The institution of Dr. Claassen has received research support from CHDI.
Manus Donahue, PhD Prof. Donahue has nothing to disclose.
Ciaran Considine, PhD (Vanderbilt University Medical Center) Dr. Considine has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for MDisrupt. Dr. Considine has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Park Dietz & Associates. The institution of Dr. Considine has received research support from NIH. The institution of Dr. Considine has received research support from DoD. The institution of Dr. Considine has received research support from Acadia Pharmaceuticals.