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Abstract Details

Effectiveness of Transcranial Alternating Current Stimulation (tACS) in Patients Having Insomnia Symptoms: A Systematic Review and Meta-analysis
Sleep
P11 - Poster Session 11 (11:45 AM-12:45 PM)
14-003
To assess the effectiveness of transcranial alternating current stimulation in patients having insomnia symptoms.
Insomnia is a common sleep disorder that affects 10% of people worldwide, impairing daily functioning, reducing quality of life, and potentially leading to chronic cognitive impairment. Transcranial alternating current stimulation (tACS) is a novel, non-invasive, and non-pharmacological intervention that may offer benefits in treating insomnia.
We systematically searched PubMed, Scopus, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception to May 2025 for relevant studies. Dichotomous outcomes were pooled as risk ratios (RR) and continuous outcomes as mean difference (MD) with 95% confidence intervals (CIs) using random-effects. The I2 and χ2 statistics were employed to evaluate inter-study heterogeneity. A P-value of <0.05 was considered statistically significant. All the calculations were performed using RevMan Web.

Five RCTs involving 369 participants were included (mean ages 48.6±14.7 to 55.3±8.0 years, 74.5% female). Most studies used daytime tACS sessions (20-40 min), targeting frontal or mastoid regions. Meta-analysis showed that tACS significantly improved global sleep quality, with reduced Pittsburgh Sleep Quality Index (PSQI) scores (MD -3.33; 95% CI: [-6.20 to -0.46]), sleep onset latency (MD -29.16 minutes; 95% CI: [-50.37 to -7.94]), total sleep time (MD 0.93 hours; 95% CI: [0.29 to 1.58]), sleep quality (MD -1.10; 95% CI: [-1.71 to -0.48]), and response rate (RR 7.45; 95% CI: [1.37-40.64]). Non-significant effects were found for Insomnia Severity Index (ISI), Hamilton Anxiety Rating (HAMA), Hamilton Depression Rating (HAMD) scores, sleep efficiency, or daily disturbances. Heterogeneity was high across outcomes.

tACS may help improve sleep quality and latency in insomnia, though more rigorous, standardized, and larger-sample trials are needed to confirm benefits.
Authors/Disclosures
Muhammad Moiz Javed, MD
PRESENTER 		Dr. Javed has nothing to disclose.
Saad Arsalan Wasti, MBBS Mr. Arsalan Wasti has nothing to disclose.
Ali Akram Qureshi, MBBS Dr. Qureshi has nothing to disclose.
Maria Qadri, MBBS Dr. Qadri has nothing to disclose.
Zainab Alvi, MBBS Dr. Alvi has nothing to disclose.
Azka Ijaz, MBBS Miss Ijaz has nothing to disclose.
Hammad Naveed, MBBS Mr. Naveed has nothing to disclose.
Mohammad Waqas Bin Waheed, MBBS Dr. Waqas Bin Waheed has nothing to disclose.
Erum Habib, Optometrist Miss Habib has nothing to disclose.
Muhammad Usman Iqbal, MBBS Mr. Iqbal has nothing to disclose.
Muhammad Nabeel Saddique, MBBS Mr. Saddique has nothing to disclose.