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Abstract Details

Reliability of Scoring Transforms of Wearable Sensor Signals in People with Parkinson’s Disease
Movement Disorders
P11 - Poster Session 11 (11:45 AM-12:45 PM)
16-007
To assess the reliability of FFT and CWT scoring in Parkinson’s disease.
Objective, scalable motor assessment is needed for the diagnosis and treatment of Parkinson’s disease (PD) and related conditions, especially in remote or resource-limited contexts. Transforming signals from wearable-sensor data from structured motor assessments may provide a low-cost complement to in-person clinical ratings, but agreement with in-person assessments for people with PD and healthy controls (HC) must be established.

Eighteen participants (11 PD, 7 HC) completed five standardized repetitive motor tasks while wearing triaxial accelerometers attached to the extremities (wrists and ankles) to capture movement signals. Raw signals were transformed into fast Fourier (FFT) and continuous wavelet (CWT) visual outputs. Trained raters, blinded to participant diagnosis and laterality, scored the transformed images of test and retest after one week. Agreement was evaluated using average-measure intraclass correlations (ICCs) from a two-way mixed-effects model with absolute agreement. Level differences between FFT and CWT ratings were assessed using Wilcoxon signed-rank tests on patient medians.

Excellent agreement was observed between blind ratings of signals and their transforms across groups and sessions: PD Test (ICC = 0.918), HC Test (ICC = 0.840), PD Retest (ICC = 0.928), HC Retest (ICC = 0.925). Wilcoxon tests showed no significant level differences between FFT and CWT: PD Test Z = −0.211, p = .833; HC Test Z = 0.000, p = 1.000; PD Retest Z = −0.879, p = .379; HC Retest Z = −1.897, p = .058.

Blind FFT and CWT visual scoring showed strong internal agreement across raters and sessions, supporting the integration of transformed wearable data into remote, clinician-augmented PD monitoring. This approach can facilitate telehealth when clinic visits are limited by infectious diseases or conflicts and may serve as a biomarker framework for clinical trials of interventions in PD and related conditions.

 

 

Authors/Disclosures
James R. Brasic, MD, FAAN (Bellevue Hospital Center)
PRESENTER
Dr. Brasic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Image Guided Therapy Research Institute. Dr. Brasic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for One World, Inc.. Dr. Brasic has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Society of Nuclear Medicine and Molecular Imaging. Dr. Brasic has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Multidisciplinary Digital Publishing Institute. Dr. Brasic has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Gerson Lehman Group, Inc..
Abdelwahab A. Elshourbagy Mr. Elshourbagy has nothing to disclose.
Liran Ziegelman, PhD Dr. Ziegelman has nothing to disclose.
Timothy J. Harrigan Mr. Harrigan has nothing to disclose.
Manuel Hernandez Manuel Hernandez has nothing to disclose.