Abstract Details

Title Sensory Sensitivities in Individuals with Tics and Tourette Syndrome

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (11:45 AM-12:45 PM)

Poster/Presentation
Number 16-007

Objective To review patterns of sensory sensitivity in patients with tics and Tourette's syndrome (TS) to gain insight into this under-reported phenomenon.

Background Patients with TS have been described in small studies to experience heightened sensitivity to tactile, auditory, and visual stimuli. This may arise from dysfunction in sensory processing rather than lowered sensory thresholds. The prevalence of increased sensory sensitivities in children and adults with TS is not yet known.

Design/Methods Patients presenting to TS clinic were sorted into adult (18 y<), adolescent (12-17 y), or pediatric (3-11y) provided the Glasgow Sensory Questionnaire (GSQ) (12y< ) or the Parent-completed Glasgow Sensory Questionnaire (P-GSQ) (11y>) with the addition of five exploratory questions assessing responses to textures, clothing, and sound. One-sample t-tests were used to compare total scores. One way ANOVA analyses were performed comparing average questionnaire scores by cohort and sensory modality averages.

Results 41 patients have been enrolled; n=26 adult, n=6 adolescent and n=9 pediatric). The average score among all cohorts was 56.85, which is significantly higher than the normative mean of 38.3 (one sample t-test t(40)=5, p<0.001, Cohen’s D=0.8) and significantly below the normative mean in ASD (one sample t-test t(40)=2.3, p=0.026, Cohen’s D=0.4). Average scores for adult, adolescent, and pediatric cohorts were 46.65, 91.50, and 54.55 respectively. These were found to be significantly different (ANOVA F=10.90, p<0.001, Tukey’s HSD with significant differences between the adolescent and adult cohort (p<0.001) and adolescent and pediatric cohort (p<0.001). Sub-analyses of sensory modality show significant differences (ANOVA F=6.49, p<0.001) among modalities, with significantly higher rates of hyper and hypo auditory sensitivity.

Conclusions There are sensory disturbances in TS and tic disorders higher than a normative threshold. Adolescents appear to have the most pronounced sensitivity. Auditory sensation appears most affected. Future work aims to consider comorbidities and further age trends.

Authors/Disclosures
Rachael Burke, MD (University of Florida Department of Neurology) PRESENTER	Dr. Burke has nothing to disclose.
Patricia Jokl Graese, MD	Dr. Graese has nothing to disclose.
Anastasia Barnes, MD	Dr. Barnes has nothing to disclose.
Irene Malaty, MD, FAAN (University of Florida)	Dr. Malaty has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aevum. The institution of Dr. Malaty has received research support from Abbvie. The institution of Dr. Malaty has received research support from Revance. The institution of Dr. Malaty has received research support from Parkinson Foundation. The institution of Dr. Malaty has received research support from SAGE. The institution of Dr. Malaty has received research support from Emalex. The institution of Dr. Malaty has received research support from Acadia. Dr. Malaty has received publishing royalties from a publication relating to health care. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Speaker & Center of Excellence Director with Parkinson Foundation. Dr. Malaty has a non-compensated relationship as a MAB member & Center of Excellence Directory with Tourette Association of America that is relevant to AAN interests or activities.

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