好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Multi-modal Digital Health Technology for Remote Monitoring of Disease Activity in Prodromal Huntington’s Disease and Huntington’s Disease
Movement Disorders
P2 - Poster Session 2 (11:45 AM-12:45 PM)
16-013
To develop and validate a multi-modal digital health technology for remote monitoring of disease activity in Huntington’s disease (HD).
HD is a neurodegenerative disorder characterized by progressive motor, cognitive, and behavioral symptoms. The principal means of measuring motor impairment in Huntington disease (HD) is the Unified Huntington’s Disease Rating Scale total motor score. Although valuable, the scale is subjective and categorical and requires significant training to administer correctly. Digital health technologies (DHTs) offer a promising approach to capture frequent objective data that can improve future clinical trials and care for HD.

We developed a multi-modal DHT solution for monitoring motor, speech and cognitive symptoms in prodromal HD and HD. The solution combines wearable sensors for monitoring physical activity, posture and hand function during activities of daily living, with tablet-based digital speech, cognitive and fine motor control assessments.

In our pilot study, sensor and speech data were collected from 18 individuals with HD, 7 with prodromal HD, and 11 healthy controls. Both speech- and sensor-derived digital features showed significant group-level differences. Machine learning–based models were developed to distinguish HD, prodromal HD, and control participants based on these digital measures.
This study highlights the potential of DHTs to enhance clinical care and research in Huntington’s disease by providing more sensitive measures of disease severity, enabling differentiation across disease stages, and facilitating prediction of disease progression.
Authors/Disclosures
Ram Kinker Mishra, PhD (Biosensics)
PRESENTER 		Dr. Mishra has received personal compensation for serving as an employee of BioSensics LLC.
Ashkan Vaziri, PhD (Biosensics LLC) Dr. Vaziri has received personal compensation for serving as an employee of Biosensics.
Daniel O. Claassen, MD, FAAN (Vanderbilt University Medical Center) Dr. Claassen has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Alterity. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Dr. Claassen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AskBio. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for University of Michigan. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cognition Therapeutics . Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amylyx. The institution of Dr. Claassen has received research support from NIH. The institution of Dr. Claassen has received research support from CHDI. The institution of Dr. Claassen has received research support from HDSA. The institution of Dr. Claassen has received research support from Department of Defense. The institution of Dr. Claassen has received research support from CHDI.
Jamie L. Adams, MD (University of Rochester Medical Center) Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Adams has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Michael J. Fox Foundation. Dr. Adams has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BioSensics. The institution of Dr. Adams has received research support from NIH/NINDS. The institution of Dr. Adams has received research support from Biogen. The institution of Dr. Adams has received research support from The Michael J. Fox Foundation. The institution of Dr. Adams has received research support from Critical Path Institute. Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a KINECT-HD Steering Committee Member with Huntington Study Group. Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a ORCHESTRA-PD Steering Committee Member with Parkinson Study Group.