Abstract Details

Title The Role of Endothelial Dysfunction Biomarkers in Acute Ischemic Stroke

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P2 - Poster Session 2 (11:45 AM-12:45 PM)

Poster/Presentation
Number 4-008

Objective To evaluate the role of endothelial dysfunction biomarkers- homocysteine, thrombomodulin and endothelin-1 in acute ischemic stroke patients, assessing their relationship with stroke.

Background Stroke remains the second leading cause of death and long-term disability worldwide, with cardiovascular diseases accounting for over 60% of all deaths in Uzbekistan. Despite advances in clinical management, early diagnostic and prognostic tools remain limited. Endothelial dysfunction is a key mechanism in ischemic stroke pathogenesis, yet biomarkers such as homocysteine, thrombomodulin, and endothelin-1 are underexplored in local populations.

Design/Methods A cross-sectional study was conducted on 180 participants (135 AIS, 29 with chronic cerebrovascular insufficiency [CCI], and 16 healthy controls) aged 44-90 years. Plasma levels of homocysteine, thrombomodulin, and endothelin-1 were measured using ELISA within 16 hours of stroke onset.

Results Biomarker levels were significantly elevated in AIS patients compared to CCI and healthy controls (p<0.001). Thrombomodulin increased from 21.25 µg/L (controls) and 25.6 µg/L (CCI) to 94.0 µg/L (AIS) a 4.4-fold rise. Endothelin-1 rose from 2.85 pg/mL and 4.92 pg/mL to 9.7 pg/mL, showing a 3.4-fold increase. Homocysteine rose from 4.25 µmol/L and 5.84 µmol/L to 19.9 µmol/L, a 4.7-fold elevation. Levels were highest in elderly AIS patients (TM = 131.75 µg/L, ET-1 = 10.8 pg/mL, Hcy = 20.6 µmol/L). Males had higher thrombomodulin and homocysteine, while females showed higher endothelin-1 values.

Conclusions Elevated endothelial dysfunction biomarkers are closely associated with the presence and severity of acute ischemic stroke. Thrombomodulin demonstrated the most pronounced rise, highlighting its potential as a key indicator of endothelial injury. These biomarkers may serve as useful adjuncts for early diagnosis and personalized management in stroke care.

Authors/Disclosures
Akash Rawat, MD, MBBS PRESENTER	Dr. Rawat has nothing to disclose.
Kalash Dwivedi, MBBS	Mr. Dwivedi has nothing to disclose.
Nargiza Maksudovna Vaxabova (Tashkent State Medical University)	No disclosure on file
Asadullayev Maqsud Maxmudovich (Tashkent State Medical University)	No disclosure on file

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