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Abstract Details

Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans
Aging, Dementia, and Behavioral Neurology
P3 - Poster Session 3 (5:00 PM-6:00 PM)
12-005

To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo[11C]GSK189254 positron emission tomography (PET) imaging.

Histamine is a neurotransmitter that plays a crucial role in regulating sleep/wakefulness, feeding, and memory processes. Histamine H3 receptors (H3R), a member of the histamine receptor family, are expressed in the cerebral cortex and striatum as well as in the peripheral nervous system. H3Rs regulate the synthesis and release of histamine as presynaptic autoreceptors and function as heteroreceptors to mediate the release of not only histamine butother neurotransmitters including acetylcholine, dopamine, noradrenaline and serotonin. Up to date, no in vivo human study has explored H3R availability with respect to age and BMI.

Twenty-four healthy individuals (2 females, 22 males; age range 20-47 years) were scanned with [11C]GSK189254 with High-Resolution Research Tomograph (HRRT) or HR plus scanner. Regional VT (volume of distribution) values were computed using the two-tissue compartment model.The correlation between VT and age, BMI were examined, adjusting for relevant potential confounding effects of age or gender and injected mass.

H3R availability (VT) was correlated with age but not BMI. VT displayed a negative correlation with age in the anterior cingulate cortex (r= -0.61, p= 0.004), frontal cortex (r= -0.50, p= 0.020), olfactory cortex (r= -0.50, p= 0.022), parietal cortex (r= -0.58, p= 0.006), cerebellum cortex (r= -0.53, p= 0.013), insula (r= -0.48, p= 0.027), putamen (r= -0.46, p= 0.034), thalamus (r= -0.45, p= 0.038), and hippocampus (r=0.45, p=0.039).

This in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.

Authors/Disclosures
Yanghong Yang, MD
PRESENTER 		Dr. Yang has nothing to disclose.
Waleed N. Ibrahim, MD Dr. Ibrahim has nothing to disclose.
Paul Gravel (Yale University) Paul Gravel has nothing to disclose.
brian pittman (Yale university) No disclosure on file
Jocelyn Hoye (Yale university) No disclosure on file
Faranak Ebrahimian Saadabad Mr. Ebrahimian Saadabad has nothing to disclose.
Ryan Cool Mr. Cool has nothing to disclose.
Mingqiang Zheng (Yale university) No disclosure on file
Christopher Pittenger, MD, PhD Dr. Pittenger has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Biohaven Pharmaceuticals. Dr. Pittenger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Freedom Biosciences. Dr. Pittenger has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB BioPharma. Dr. Pittenger has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for lucid.care. Dr. Pittenger has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Mind Therapeutics. Dr. Pittenger has stock in Alco Therapeutics. Dr. Pittenger has stock in Mind Therapeutics. The institution of Dr. Pittenger has received research support from Biohaven Pharmaceuticals. The institution of Dr. Pittenger has received research support from Biohaven Pharmaceuticals. Dr. Pittenger has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittenger has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittenger has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittenger has received publishing royalties from a publication relating to health care. Dr. Pittenger has received publishing royalties from a publication relating to health care.
Jean-Dominique Gallezot The institution of Jean-Dominique Gallezot has received research support from Intra-cellular Therapies, Inc.. The institution of an immediate family member of Jean-Dominique Gallezot has received research support from Cerevel.
Richard E Carson The institution of Richard E Carson has received research support from Cerevel. The institution of Richard E Carson has received research support from Pfizer.
Yiyun Huang Yiyun Huang has nothing to disclose.
RAJIV RADHAKRISHNAN, MD Dr. RADHAKRISHNAN has received personal compensation for serving as an employee of BMS. The institution of Dr. RADHAKRISHNAN has received research support from Jazz Pharmaceuticals.
David Matuskey, MD (Yale University) Dr. Matuskey has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Eleisver. The institution of Dr. Matuskey has received research support from Abbvie.