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Abstract Details

Overlap of Parkinson's Disease and Respiratory Failure in Older Adults: Epidemiologic Insights from CDC-WONDER Database (1999-2020)
Movement Disorders
P3 - Poster Session 3 (5:00 PM-6:00 PM)
16-008
To assess mortality trends due to the overlap of PD and respiratory failure in older U.S. adults from 1999 to 2020, highlighting the disparities across demographics and regions.

Parkinson’s disease (PD) is the second leading neurodegenerative disorder. Beyond just motor dysfunction, PD contributes to respiratory impairment through muscle weakness, rigidity, and airway obstruction. Respiratory failure is recognized as a significant cause of mortality in advanced PD.

We analyzed PD (ICD-10 code: G20) and respiratory failure (ICD-10 code: J96) mortality in the elderly, using the CDC-WONDER database from 1999 to 2020. Age-Adjusted Mortality Rates (AAMRs) per 100,000 were calculated and categorized by demographics and region. Joinpoint regression was used to estimate Annual Percent Change (APC) and Average Annual Percent Change (AAPC).
From 1999 to 2020, a total of 59,168 PD-related respiratory failure deaths were recorded among elderly aged ≥65 years. The AAMR observed a significantly marked incline from 5.5 to 11.3 (AAPC: 7.4; 95% CI: 6.5 to 8.4, p<0.01). Men had higher overall AAMR (10.5) than women (3.9). Racially, Non-Hispanic (NH) White population had the highest overall AAMR (6.8), and NH Black (3.5) had the lowest. Regionally, the highest overall AAMR was recorded by the West (8.3), followed by the Northeast (6.9), the South (5.9) and the Midwest (5.3). Non-metropolitan areas had lower AAMR than metropolitan areas (5.8 vs 6.6). States that fell in the top 90th percentile were Nebraska, California, Connecticut, and Mississippi.

This study highlights a marked rise in PD–related respiratory failure deaths in the U.S. from 1999 to 2020, with notable disparities. Mortality was higher in males, NH Whites, and the West. Rural areas experienced a pronounced surge, reflecting limited access to special care. These findings underscore widening inequities, the need for targeted policies, and equitable resource allocation in high-risk and vulnerable groups.
Authors/Disclosures
Amna A. Jalal, MBBS
PRESENTER 		Dr. Jalal has nothing to disclose.
Maryam Saghir, MBBS Miss Saghir has nothing to disclose.
Kashmala Rahl, MBBS Dr. Rahl has nothing to disclose.
Eshal Saghir, MBBS Miss Saghir has nothing to disclose.
Muhammad Hamza Shoaib, MBBS Mr. Shoaib has nothing to disclose.
Muhammad Affan, MBBS Dr. Affan has nothing to disclose.
Mahtab zafar, MBBS Dr. zafar has nothing to disclose.
Nara Michaelson, MD (Beth Israel Deaconess Medical Center) The institution of Dr. Michaelson has received research support from Biogen. The institution of Dr. Michaelson has received research support from the National Multiple Sclerosis Society (NMSS). Dr. Michaelson has received research support from Sanofi.