Abstract Details

Title Alcohol Use Disorder in Seizure-related Hospitalizations: Insights from the 2022 National Inpatient Sample

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 11-007

Objective To compare demographics, hospitalization characteristics, and comorbid depression between patients hospitalized with seizure alone and those with seizure plus alcohol use disorder

Background Seizures are a common cause of hospital admissions in the United States, and alcohol use disorder (AUD) frequently co-occurs, potentially influencing demographics, clinical characteristics, and comorbidities. This study examines differences between patients hospitalized with seizure alone and those with seizure plus AUD, including the prevalence of comorbid depression.

Design/Methods Hospitalizations with a primary ICD-10 diagnosis of seizure (DXCCSR=NVS009) were identified in the 2022 National Inpatient Sample (NIS) and stratified into seizure-only and seizure with secondary diagnosis of AUD (F10*). Demographics (age, sex, race), hospitalization characteristics (length of stay, total charges), and clinical outcomes (mortality, discharge disposition) were compared using t-tests for continuous variables and chi-square tests for categorical variables. Comorbid depression (F32*) was also assessed.

Results A total of 54,571 patients were hospitalized with seizures, including 5,544 with seizure plus AUD. Patients with seizures and AUD were more likely to be male (72.7% vs. 49.8%, p<0.001) and older (mean 51.1 vs. 43.3 years). Racial distribution differed significantly, with higher proportions of White and Black patients in the AUD group (p<0.001). Length of stay was slightly longer in the AUD group (4.88 vs. 4.35 days), while total charges were similar ($61,996 vs. $61,971). In-hospital mortality was low and comparable (0.9% vs. 1.0%, p=NS). Comorbid depression was more prevalent in the seizure + AUD group (17.8% vs. 13.7%, p<0.001).

Conclusions

Hospitalized seizure patients with comorbid AUD represent a distinct subgroup characterized by older age, male predominance, slightly longer hospital stays, and higher prevalence of depression. These findings highlight the importance of screening for alcohol use and psychiatric comorbidities to optimize inpatient care and discharge planning.

Authors/Disclosures
Arun R. Antony, MD (Jersey Shore University Medical Center) PRESENTER	Dr. Antony has nothing to disclose.
David George, High School Student	Mr. George has nothing to disclose.
Diji Johnson, MBBS	Dr. Johnson has nothing to disclose.

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