Abstract Details

Title Age Enhancing Cognitive Ability Shows Similar Attenuation in the Task Evoked Brain Networks with Aging and Preclinical AD

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 12-008

Objective In this study, we propose to study brain networks functional connectivity at rest as well as the networks’ task-evoked BOLD response during two different tasks that have previously shown both age-related decline and improvement in performance

Background Brain aging - with and without pre-clinical Alzheimer’s disease (AD) pathology - are associated with deterioration in the brain networks’ coherence and/or co-activation/deactivation as well as with decline in most cognitive abilities, paving the road for a network-based conceptualization of the brain normal versus pathological aging. However, certain cognitive abilities, like crystallized memory, improve with age, which complicates the explanation of these changes solely through age-related decline in the brain networks.

Design/Methods Cross-sectional cohort of 259 participants (62 young, and 197 older), who underwent two task-based (one declining and another improving with age), and one resting-state fMRI scans, plus a positron emission tomography scan (to determine preclinical amyloid accumulation)

Results We found that the brain networks’ co-activation/deactivation, but not coherence, significantly attenuate with age and/or AD pathology even in the task for which performance improves by age. Interestingly, we also found that an increase in the networks’ co-activation/deactivation, but not coherence, was associated with an improvement in task performance. Finally, we provided preliminary evidence that the brain networks lose their task-evoked deactivations with age before their coherence.

Conclusions These findings shed light on the process of functional aging in the brain networks, differentiate functional aging of the brain networks’ coherence at rest versus their task-evoked co-activation/deactivation, and emphasize the more dominant role of the task-evoked brain activity in understanding aging brain function and distinguishing it from preclinical AD.

Authors/Disclosures
Peter Chernek, MPH PRESENTER	Mr. Chernek has nothing to disclose.
Bardiya Ghaderi Yazdi, MD	Dr. Ghaderi Yazdi has nothing to disclose.
Seyed Hani Hojjati, PhD	Dr. Hojjati has nothing to disclose.
Sindy ozoria blake	Mrs. ozoria blake has nothing to disclose.
Jenseric Calimag	Mr. Calimag has nothing to disclose.
Xiuyuan H. Wang	Mr. Wang has nothing to disclose.
Gloria Chiang	Gloria Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Life Molecular Imaging. Gloria Chiang has received personal compensation in the range of $0-$499 for serving as a Consultant for Alnylam. The institution of Gloria Chiang has received research support from Minoryx Therapeutics. The institution of Gloria Chiang has received research support from National Institutes of Health. Gloria Chiang has received personal compensation in the range of $5,000-$9,999 for serving as a speaker with Efficient CME. Gloria Chiang has received personal compensation in the range of $500-$4,999 for serving as a speaker with PeerView.
Ray Razlighi, PhD	Prof. Razlighi has nothing to disclose.

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