Abstract Details

Title Association of Dietary Fiber Intake with Dementia Incidence Among Community-dwelling Older Adults

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 13-009

Objective To examine the association between dietary fiber intake and dementia incidence in older adults.

Background Dementia is a leading risk factor for death among older adults in the United States. Healthy dietary patterns rich in fiber have been linked to lower dementia risk. Fiber may promote brain health by improving glycemic control, regulating gut–brain communication, and reducing inflammation. Fiber intake among U.S. adults is well below recommended levels, and few studies have examined the associations of fiber intake, specifically soluble and insoluble fiber, with incident dementia.

Design/Methods Community-dwelling older participants (81±7 years; 75% female) from the ongoing prospective Rush Memory and Aging Project reported their usual diet at annual visits by completing a validated Food Frequency Questionnaire (FFQ) from which calorie-adjusted total, soluble, and insoluble fiber (g/day) were calculated. We selected 1,526 participants who had no history of dementia at the first FFQ and at least one complete clinical assessment after dietary data collection. Dementia was determined through annual clinical evaluations and consensus diagnosis using NINCDS/ADRDA criteria. Cox proportional hazards models of censored time to dementia with adjustment for age, sex, education, BMI, physical activity, calories, and ApoE-ε4 were used.

Results During 6.9 (±4.6) years of follow-up, 430 (28.2%) participants were diagnosed with incident dementia. Higher intake of total fiber at baseline was associated with lower rates of incident dementia (Q5 vs. Q1: HR=0.66, 95%CI 0.45-0.96, p-trend=0.04). The association remained after further adjusting for vitamin E, folate, omega-3, and lutein. In a sub-sample (n=606), those in the highest quintile of insoluble fiber intake had 54% lower incidence of dementia compared to those in the lowest quintile (Q5 vs. Q1: HR=0.46, 95%CI 0.25-0.86, p-trend=0.01); however, soluble fiber had no significant associations with incident dementia.

Conclusions Higher total dietary fiber intake, particularly insoluble fiber, is associated with lower rates of incident dementia.

Authors/Disclosures
Nicole Glick PRESENTER	Ms. Glick has nothing to disclose.
Maude Wagner, PhD	Dr. Wagner has nothing to disclose.
fran grodstein, PhD	The institution of Dr. grodstein has received research support from nih. Dr. grodstein has received publishing royalties from a publication relating to health care.
Sue E. Leurgans, PhD	Dr. Leurgans has nothing to disclose.
Lisa L. Barnes, PhD (Rush University Medical Center)	Lisa L. Barnes has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer's & Dementia. The institution of Lisa L. Barnes has received research support from NIH. Lisa L. Barnes has received personal compensation in the range of $500-$4,999 for serving as a Council member with NACMHD.
David A. Bennett, MD (Rush University Medical Center)	Dr. Bennett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Annovis. Dr. Bennett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for New Amsterdam. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie.
Julie A. Schneider, MD, MS (Rush Alzheimer'S Disease Center)	Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for alnylam. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for apellis. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for National Hockey League. The institution of Dr. Schneider has received research support from NIH. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a scientific advisor with Fondation Alzheimer, France.
Puja Agarwal, PhD, MBA (Rush University Medical Center)	The institution of Dr. Agarwal has received research support from Michael J Fox Foundation for Parkinson's Research. The institution of Dr. Agarwal has received research support from National Institute on Health.

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