Abstract Details

Title Concordance of Functional and Patient-reported Outcome Measures to GOSE in a Subacute-chronic Traumatic Brain Injury Clinic Population

Topic Neuro-rehabilitation

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 14-006

Objective

To investigate the concordance of functional and patient-reported outcome measures (PROMs) compared to Glasgow Outcome Scale–Extended (GOSE) in subacute-chronic traumatic brain injury (TBI) clinic patients.

Background

GOSE is the current gold standard for measuring functional outcome after TBI and emphasizes patients’ return to work and functional independence. However, the complete spectrum of recovery is not represented with GOSE and including PROMs such as social reintegration may better encapsulate a patient-centric recovery after TBI.

Design/Methods

A retrospective (7/2024-8/2025) cohort study of a single-center TBI clinic was performed. Functional outcomes included: Modified Rankin Scale (mRS); Rivermead Post-Concussion Symptoms Questionnaire (RPQ); Montreal Cognitive Assessment (MoCA). PROMs included NIH PROMIS surveys: Psychosocial Illness Impact (PII); Self-Efficacy; Social Roles and Activities (SRA). Inclusion criteria: ≥ 18 years old, GOSE, TBI diagnosis per American-Congress-Rehabilitation-Medicine criteria, at least one functional outcome measure or PROM. mRS and RPQ are reverse-scored compared to GOSE. Kendall’s tau and Spearman’s correlation were performed.

Results

183 TBI patients (mean age=46, 44.3% female, 76% mild TBI) were analyzed. There was moderate concordance between GOSE and mRS (tau=-0.617, p<.0001), SRA (tau=.467, p<.0001), and Self-Efficacy (tau=.401, p<.0001). Weaker concordance with GOSE was observed with RPQ (tau=-0.268, p<.0001), PII (tau=.202, p=.006), and MoCA (tau=.171, p=.039).

Moderate correlations with GOSE were observed with mRS (rho=-0.693, p<.0001), SRA (rho=.583, p<.0001), and Self-Efficacy (rho=.499, p<.0001), while weaker correlations with GOSE were seen with RPQ (rho=-0.349, p<.0001), PII (rho=.259, p=.007), and MoCA (rho=.226, p=.037).

Conclusions

Though there was general concordance across all measures with GOSE, not all were strong concordant relationships, indicating some underrepresented considerations for recovery when using GOSE and the potential benefit of supplementing GOSE with specific PROMs such as social reintegration and self-efficacy to track TBI recovery.

Authors/Disclosures
Amanda Fang, Undergraduate student PRESENTER	Miss Fang has nothing to disclose.
Stephania B. Tovar Vargas, MPH	Ms. Tovar Vargas has nothing to disclose.
Maral Sakayan, MD (UCI Department of Neurology)	Dr. Sakayan has nothing to disclose.
Maria Thereza Paulino	Miss Paulino has nothing to disclose.
Alexis Conrad (Neurology Traumatic Brain Injury & Concussion (NTBIC) Program, Department of Neurology, University of California, Irvine, Orange, CA)	No disclosure on file
Arunima Kapoor	Ms. Kapoor has nothing to disclose.
Danh V. Nguyen, PhD	Prof. Nguyen has nothing to disclose.
Mark Mapstone, PhD (University of California, Irvine)	Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Brain Neurotherapy Bio, Inc. Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon, Inc. Dr. Mapstone has received intellectual property interests from a discovery or technology relating to health care.
Sigrid Burruss, MD	The institution of Dr. Burruss has received research support from BSCC CalVIP.
Jeffry Nahmias, MD, MHPE	Dr. Nahmias has nothing to disclose.
Michael Lopez, PhD	Michael Lopez has nothing to disclose.
Bernadette Boden-Albala, DrPH (University California Irvine)	Ms. Boden-Albala has received research support from NIH.
Patrick M. Chen, MD (UC Irvine Medical Center)	Dr. Chen has nothing to disclose.

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