Abstract Details

Title Exploratory Analysis of Changes in Patient-perceived Stress Throughout Traumatic Brain Injury Recovery

Topic Neuro-rehabilitation

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 14-010

Objective

To explore longitudinal changes in patient-perceived stress following traumatic brain injury (TBI).

Background With growing recognition of TBI as a chronic condition, there is an increasing need to better characterize patterns in patient-perceived stress and identify factors contributing to prolonged stress.

Design/Methods A single-center longitudinal cohort study was performed including all TBI patients evaluated within 3 weeks of injury in our TBI clinic (4/2024-9/2025). Primary outcome: Perceived Stress Scale (0-16) at initial clinic visit (PSS1), 6-month follow-up (PSS2), and change from PSS1 to PSS2. Descriptive and univariate statistics were performed.

Results There were 31 patients who completed both PSS1 and PSS2 (mean age 48 ±17; 54.8% female; 35.5% white; 80.6% mild TBI). Median PSS1 was 8 (IQR, 2.5-10) and median PSS2 was 5 (IQR, 2-9). From PSS1 to PSS2, 0 patients reported an increase in stress level, 26 (83.9%) reported no change in stress level, while 5 (16.1%) reported a decrease in stress. Among these 5 patients, the median decrease in PSS was 6 points (IQR, 5-7) or 54.5% decrease in score. There were no significant differences in demographics, TBI-severity, premorbid psychiatric conditions, or Glasgow Outcome Scale-Extended (GOSE) score between the improved vs. non-improved cohort. There was higher initial PSS (11 vs 5.5, p=0.024) and a higher proportion with private insurance (80% vs 23.1%, p=0.027) in those with improved versus static stress.

Conclusions Stress is chronic and persistent following TBI, with 83.9% of patients with static PSS 6 months post-TBI. Patients with higher levels of initial stress more often demonstrated improvements in stress longitudinally. Private insurance was associated with improvement in stress in this exploratory analysis, likely pointing to an outcome disparity driven by determinants of health.

Authors/Disclosures
Maria Thereza Paulino PRESENTER	Miss Paulino has nothing to disclose.
Amanda Fang, Undergraduate student	Miss Fang has nothing to disclose.
Stephania B. Tovar Vargas, MPH	Ms. Tovar Vargas has nothing to disclose.
Maral Sakayan, MD (UCI Department of Neurology)	Dr. Sakayan has nothing to disclose.
Danh V. Nguyen, PhD	Prof. Nguyen has nothing to disclose.
Mark Mapstone, PhD (University of California, Irvine)	Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Brain Neurotherapy Bio, Inc. Dr. Mapstone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon, Inc. Dr. Mapstone has received intellectual property interests from a discovery or technology relating to health care.
Sigrid Burruss, MD	The institution of Dr. Burruss has received research support from BSCC CalVIP.
Areg Grigorian	Areg Grigorian has nothing to disclose.
Jeffry Nahmias, MD, MHPE	Dr. Nahmias has nothing to disclose.
Michael Lopez, PhD	Michael Lopez has nothing to disclose.
Bernadette Boden-Albala, DrPH (University California Irvine)	Ms. Boden-Albala has received research support from NIH.
Patrick M. Chen, MD (UC Irvine Medical Center)	Dr. Chen has nothing to disclose.

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