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Abstract Details

Diet, Leukocyte Telomere Length, and Disability in Multiple Sclerosis
Multiple Sclerosis
P4 - Poster Session 4 (8:00 AM-9:00 AM)
18-003

Evaluate relationships among dietary habits, biological aging markers and disability metrics in MS.
Previous work has established associations between MS-related disability and 1. dietary habits and 2. leukocyte telomere length (LTL) as a marker of biological aging. Here we evaluate relationships among diet, LTL, and disability in a cohort of people with early MS.     

 

Using samples collected from the RADIEMS (Reserve against Disability in Early MS) research cohort (n=172, age range 24-56), we measured LTL as telomere to somatic DNA ratios (T/S ratio) using real time quantitative PCR assays. Dietary analysis used the Mediterranean Diet Adherence Screener (MEDAS, scored 0-14, lower score indicates lower Mediterranean alignment); participants were divided into MEDAS quartiles. ANCOVA tested for differences in LTL across MEDAS quartiles, adjusting for age, sex, socioeconomic status, body mass index, and physical exercise. Disability worsening was defined as a 20% decline on any component (gait speed, upper extremity coordination, cognition) of the MS Functional Composite over the previous three to six years.  Separate logistic regression models were employed   to demonstrate association of disability worsening with MEDAS quartile and LTL, adjusting for aforementioned covariates.
There  was a main effect of MEDAS on LTL (F[3,163]=5.81, p<0.001, ηp2=0.097) whereby LTL was lower in MEDAS Q1 (mean [95%CI]; 0.96 [0.91, 1.02]) than Q2 (1.10 [1.06, 1.15]), Q3 (1.10 [1.04, 1.17]), and Q4 (1.07 [1.02, 1.12]). Lower MEDAS score was associated with higher risk for longitudinal disability worsening on MSFC (p=0.003, OR [95%CI] 0.691 [0.543, 0.881]).  Lower LTL was associated with worse EDSS at Year 6.  
Better alignment of dietary habits with a Mediterranean pattern is associated with longer LTL as well as with decreased risk for disability worsening over time. Further analyses will examine LTL and other biological aging metrics in this cohort in greater detail.
Authors/Disclosures
Ilana B. Katz Sand, MD (Corinne Goldsmith Dickinson Center for MS)
PRESENTER 		The institution of Dr. Katz Sand has received research support from National Multiple Sclerosis Society. The institution of Dr. Katz Sand has received research support from Hirschl Foundation. The institution of Dr. Katz Sand has received research support from National Institutes of Health. Dr. Katz Sand has received personal compensation in the range of $500-$4,999 for serving as a Conference presenter with 好色先生.
Claire E. Wigley, BSPH, BSc Ms. Wigley has nothing to disclose.
Kathryn Fitzgerald, PhD (Johns Hopkins University) Dr. Fitzgerald has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Setpoint Medical. The institution of Dr. Fitzgerald has received research support from NIH. The institution of Dr. Fitzgerald has received research support from National MS Society.
Robin Graney, Research Coordinator Ms. Graney has nothing to disclose.
Cesar Garcia Mr. Garcia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pareto.
Maria A. Piedrabuena, MD No disclosure on file
Francesco La Rosa, PhD Dr. La Rosa has nothing to disclose.
Emma Dereskewicz Ms. Dereskewicz has nothing to disclose.
Kamso Onyemeh, MS Mr. Onyemeh has nothing to disclose.
Erin S. Beck, MD (Icahn School of Medicine at Mount Sinai) Dr. Beck has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. An immediate family member of Dr. Beck has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion Pharmaceuticals. An immediate family member of Dr. Beck has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Glaxo Smith Kline. An immediate family member of Dr. Beck has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis Pharmaceutical Corporation. An immediate family member of Dr. Beck has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Swedish Orphan Biovitrum AB. The institution of Dr. Beck has received research support from National Multiple Sclerosis Society. The institution of Dr. Beck has received research support from National Institutes of Health. The institution of Dr. Beck has received research support from United States Department of Defense. The institution of Dr. Beck has received research support from Consortium of Multiple Sclerosis Centers. Dr. Beck has received intellectual property interests from a discovery or technology relating to health care.
James F. Sumowski (Icahn School of Medicine At Mount Sinai) Mr. Sumowski has nothing to disclose.
Jennifer Graves, MD, PhD (UCSD) Dr. Graves has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TG Therapeutics. Dr. Graves has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon. Dr. Graves has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MSJ. The institution of Dr. Graves has received research support from Octave. The institution of Dr. Graves has received research support from Sanofi. The institution of Dr. Graves has received research support from EMD Serono.