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Abstract Details

OCT-derived Retinal Measures Correlate With Brain-predicted Age, Neurodegeneration, and Disease Progression in Multiple Sclerosis
Multiple Sclerosis
P4 - Poster Session 4 (8:00 AM-9:00 AM)
18-006
To investigate associations between brain-predicted age, age gap (BA-CA), and OCT-derived retinal measures in MS patients.
Brain aging and neurodegeneration are hallmarks of multiple sclerosis (MS), often accompanied by structural changes in the retina. Optical coherence tomography (OCT) provides a non-invasive tool to assess retinal thinning, which may serve as a biomarker for neurodegeneration. This study investigates the relationship between chronological age (CA), brain-predicted age (BA), and retinal measures in MS patients, aiming to identify key correlations that could inform disease progression and treatment response.
In this cross-sectional study, 98 MS patients underwent whole-brain MRI scans on a SIEMENS 3T system and OCT scans on a Heidelberg SPECTRALIS platform.  3D T1-weighted images were processed with the brainageR package using Gaussian process regression to estimate BA. Spearman’s correlation using SPSS (v29) was used to assess relationships between CA, BA, age gap, and multiple OCT parameters.

Significant negative correlations were observed between BA and retinal measures, including global retinal thickness (G) (r=-0.299, p=0.004), papillomacular bundle thickness (PMB) (r=-0.340, p=0.001), retinal nerve fiber layer volume (RNFL) (r=-0.256, p=0.014), and ganglion cell and inner plexiform layer thickness (GCIPL) (r=-0.285, p=0.006). Age gap was also negatively associated with G (r=-0.266, p=0.011), PMB (r=-0.373, p<0.001), RNFL (r=-0.264, p=0.011), and GCIPL (r=-0.275, p=0.008). Higher EDSS scores were significantly associated with reduced temporal thickness (r=-0.236, p=0.025) and RNFL thickness (r=-0.246, p=0.020), suggesting that some retinal structural changes parallel clinical disability in MS. 

Faster brain aging, as indicated by a larger age gap, is associated with significant retinal thinning across multiple OCT parameters, which also correlate with EDSS in MS patients. These findings support the use of OCT-derived retinal measures as potential biomarkers for brain aging and neurodegeneration in MS. Further studies are warranted to validate these results and explore their utility in monitoring disease progression and treatment efficacy.
Authors/Disclosures
Anas Z. Nourelden, MD
PRESENTER 		Dr. Nourelden has nothing to disclose.
Fen Bao Fen Bao has nothing to disclose.
ZL Liaquat (Wayne State University) ZL Liaquat has nothing to disclose.
Carla E. Santiago-Martinez (Wayne State University) Ms. Santiago-Martinez has nothing to disclose.
Anza B. Memon, MD, FAAN (Wayne State University, SOM, Detroit, MI) Dr. Memon has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Inlightened. Dr. Memon has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Connected Research. Dr. Memon has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon Therapeutic . The institution of Dr. Memon has received research support from Genentech. The institution of Dr. Memon has received research support from TG Therapeutics.