Abstract Details

Title Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-009

Objective

: To assess the diagnostic accuracy of matrix metalloproteinase (MMP) levels in predicting hemorrhagic transformation (HT) after acute ischemic stroke (AIS).

Background

MMP-9 contributes to neuroinflammation and blood–brain barrier disruption following AIS and may serve as a plausible blood biomarker for HT.

Design/Methods A comprehensive systematic search of Medline (via PubMed), Scopus, Web of Science, Cochrane Library, and EMBASE was conducted to identify studies measuring MMP-9 in patients with AIS and HT. The mean difference between patients with AIS and HT and those without HT was calculated. Heterogeneity was assessed using the chi-square test and the I² statistic. Diagnostic test accuracy was evaluated, and the area under the curve (AUC) was plotted using Meta-DiSc software.

Results Nine studies involving 1,051 participants (641 men and 560 women) were included. MMP-9 levels were significantly higher in patients with HT, with a pooled mean difference of 70.51 ng/mL (95% CI: 35.47–105.5). The pooled diagnostic sensitivity and specificity were 79% (95% CI: 0.791–0.841) and 80% (95% CI: 0.673–0.881), respectively. The combined positive likelihood ratio was 3.88, the negative likelihood ratio 0.26, and the diagnostic odds ratio 14.75, with no significant heterogeneity (I² = 0).

Conclusions MMP-9 levels are significantly higher in patients who develop HT after AIS. Moreover, MMP-9 demonstrates good diagnostic accuracy and may serve as a useful predictive biomarker for HT.

Authors/Disclosures
Bassel E. Alrabadi, MD PRESENTER	Dr. Alrabadi has nothing to disclose.
Ahmad Alkasem, MD	Dr. Alkasem has nothing to disclose.
Esraa M. Mohammed Marei, DO, PhD	Dr. Mohammed Marei has nothing to disclose.
Elsayed K. kshk	Dr. kshk has nothing to disclose.
Anas M. Elgenidi, MD	Dr. Elgenidi has nothing to disclose.

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