To investigate the clinical characteristics, management and outcomes of cerebral venous thrombosis (CVT) patients with antiphospholipid syndrome (APS) in a Chinese cohort. This work seeks to provide a foundation for the development of diagnostic strategies in APS-associated CVT.  

     CVT is a relatively rare but severe subtype of stroke. The diagnosis of CVT is difficult. The risk factors for CVT are diverse and complex. Early diagnosis and appropriate treatment are essential for reducing complications. 

    APS is a systemic autoimmune disorder. CVT is a relatively rare and historically underrecognized manifestation of APS. And APS is a significant risk factor for CVT. APS associated CVT patients may present with atypical features,  differing from non-APS-CVT. The clinical and neuroimaging characteristics, and prognosis of APS-CVT patients remain inadequately understood.

     APS represents a significant risk factor for CVT. APS-CVT primarily affects young individuals and women, often presents insidiously, and is frequently accompanied extracranial venous thrombosis.  Its diagnosis is challenging, so screening for APS should be considered in CVT patients in such clinical contexts. The distinct venous sinus involvement in APS-CVT may reveal unique pathogenesis. Most patients were treated with warfarin, which may be associated with a favorable outcome.