Abstract Details

Title Dual Threat: Arrhythmia and Alzheimer's Mortality Trends in US Adults (1999-2023)

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 12-003

Objective This study aims to quantify the mortality burden of cardiac arrhythmias in patients with Alzheimer’s disease using CDC data.

Background Both Alzheimer’s disease and cardiac arrhythmias are leading causes of death in the U.S., frequently coexisting and compounding survival risks. Yet, their combined mortality burden remains poorly quantified, underscoring the need for population-level analysis using CDC mortality data.

Design/Methods This study used CDC WONDER data to calculate age-adjusted mortality rates (AAMR) per 100,000. Join point regression estimated Average Annual Percentage Changes (AAPC), with trends analyzed by year, sex, race, age, place of death, and region for AD-related cardiac arrhythmia mortality.

Results Between 1999 and 2023, there were 651416 recorded cases of cardiac arrhythmias in AD patients aged 25 and over. Age-adjusted mortality rate (AAMR) increased from 5.71 to 15.02 between 1999 and 2023, with an AAPC of 3.84* (95% CI: 3.35-4.48). Furthermore, the AAMR of women (11.31) was somewhat greater than that of men (11.25). Significant racial differences were seen among the races, with the highest death rates among NH Whites (12.34), NH Blacks (8.48), Hispanics (6.16), and NH Asians (4.71). When urbanization was considered, nonmetropolitan regions had higher death rates (12.15) than metropolitan areas (10.83). The Midwestern area (12.26) has the highest death rate among the US census regions, followed by the Western (11.82), Southern (11.29), and Northeastern (9.97) regions. The crude death rate was highest among older people (57.20) and lowest among middle-aged adults (0.16). From 1999 to 2020, Vermont had one of the highest death rates (19.93) while Nevada had the lowest (4.86). In 2021–2023, Oklahoma had one of the highest death rates (38.22), while Illinois had the lowest (9.53).

Conclusions Cardiac arrhythmia deaths in people with Alzheimer’s have more than doubled. Better screening, fair access to heart care, and region-focused prevention efforts are needed to reduce these growing gaps.

Authors/Disclosures
Dhyey Sidhpura, MD PRESENTER	Dr. Sidhpura has nothing to disclose.
Shahreena Athar Siddiqui, MBBS	Dr. Siddiqui has nothing to disclose.
Huzaifa S. Nawaz, MBBS	Dr. Nawaz has nothing to disclose.
Mahreen Sangrasi, MBBS, MBBS student	Miss Sangrasi has nothing to disclose.
Syed Muhammad Uzair, MBBS	Dr. Uzair has nothing to disclose.
Tahir Munir	Dr. Munir has nothing to disclose.
Laiba Sultan, MBBS	Dr. Sultan has nothing to disclose.
Nafila Zeeshan, MBBS	Miss Zeeshan has nothing to disclose.
Hafiz Sohail Ashraf, MD	Dr. Ashraf has nothing to disclose.

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