To evaluate the comparative performance of three variations (standard; burst frequency variation, BFV; pulse frequency variation, PFV) of Cala TAPS^TM therapy across a multiple-study clinical paradigm in essential tremor (ET) patients. 

Initial patient-level analysis indicates many patients receive greater response to variable TAPS modes than standard TAPS. This report presents findings from clinician-rated scales and bilateral assessments aimed at optimizing stimulation patterns. 

This report includes data from a series of prospective, randomized studies comparing standard TAPS, BFV-TAPS, and PFV-TAPS in ET patients. Analysis will include a total of 78 patients (28 completed, 50 ongoing) with functionally limiting upper limb tremor enrolled in 6-week studies with 2 weeks on each therapy. Effectiveness was assessed via clinician-rated Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS) performance subscale and patient-reported Bain and Findley Activities of Daily Living scores. TETRAS assessments were conducted bilaterally pre- and post-stimulation in the completed cohort (N=28), with calculation of mean TETRAS improvement and the proportion of patients achieving benefit (≥1-point improvement).