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Abstract Details

Correlation Between Visual Network Integrity and Visual Function in Multiple Sclerosis Patients
Multiple Sclerosis
P5 - Poster Session 5 (11:45 AM-12:45 PM)
19-005
This study aimed to pinpoint cortical nodes in the visual network whose functional integrity is associated with visual disability in MS.

Visual dysfunction is a disabling symptom in multiple sclerosis (MS), traditionally linked to demyelination of the anterior visual pathways. However, the role of cortical network integrity, specifically in higher-order visual association areas, in clinical visual impairment is not fully understood.

Cross-sectional study with 20 MS patients. Resting-state functional MRI (rs-fMRI) was used to assess intrinsic brain activity. The visual resting-state network was identified using group-level Independent Component Analysis (ICA). To examine the relationship between the visual network's intrinsic connectivity and clinical visual function, measured by the Functional Systems Visual (FS Visual) score of the Expanded Disability Status Scale (EDSS), a whole-brain, voxel-wise regression analysis was conducted. Age and sex were covariates.
The analysis revealed a significant negative correlation between intrinsic connectivity and FS Visual scores, localized to a single cluster in the right hemisphere. This statistically significant cluster (p-FDR = 0.035) was centered in the right posterior inferior temporal gyrus (pITG) (MNI coordinates: +48, -24, -24). The negative correlation means that reduced functional connectivity in this region was associated with worse visual function. A data-driven meta-analysis confirmed the right pITG's robust association with higher-order visual processing, including functions like reading and face recognition.
Reduced functional integrity of the right pITG, a key node in the ventral visual stream, is a neural correlate of visual impairment in MS. The pathophysiology of visual disability in MS extends beyond damage to the anterior visual pathways to include cortical dysfunction in areas responsible for complex visual interpretation. The observed hypoconnectivity linked to worse function supports a model of maladaptive neuroplasticity or "network collapse" within the visual system, making the right pITG a potential imaging biomarker for higher-order component of visual disability in MS.
Authors/Disclosures
Vanessa Dias Veloso, MD (Yale New Haven Hospital)
PRESENTER 		Dr. Dias Veloso has nothing to disclose.
Jonadab Dos Santos Silva, MD, PhD Dr. Dos Santos Silva has nothing to disclose.
Viviane T. Carvalho, MD (Federal Fluminense University) Dr. Carvalho has nothing to disclose.
Sarita Walvekar, MD Sarita Walvekar has nothing to disclose.
Luciana S. Azambuja, Sr., PhD Dr. Azambuja has nothing to disclose.
Adriana G. Pereira, PhD Dr. Pereira has nothing to disclose.
Giordani Passos Dr. Passos has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AstraZeneca. Dr. Passos has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Passos has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for AstraZeneca. Dr. Passos has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for EMS. Dr. Passos has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Passos has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Passos has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis.
Douglas K. Sato, MD Dr. Sato has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Sato has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Sato has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Sato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon. Dr. Sato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Sato has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Astra-Zeneca. The institution of Dr. Sato has received research support from Biogen. The institution of Dr. Sato has received research support from Merck.
Jefferson Becker, MD, PhD (WorldPharma) Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AMGEN. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ROCHE. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ASTRAZENECA. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SANOFI. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MERCK. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ROCHE. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AMGEN. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for MERCK. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ASTRAZENRCA. Dr. Becker has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for EMS.