好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Multimodal Analysis of Brain Networks Contributes to Characterize Clinical Profiles in Multiple Sclerosis
Multiple Sclerosis
P5 - Poster Session 5 (11:45 AM-12:45 PM)
19-009
To perform a multimodal analysis of grey matter (GM) structural and functional networks in a multicenter cohort (12 European sites) to evaluate the contribution of structural/functional MRI GM damage in depicting multiple sclerosis (MS) clinical features.
MS is characterized by significant variability in clinical manifestations, likely because of the wide heterogeneity in the distribution of structural brain damage and the varying efficiency of brain plasticity across patients.
3D T1-weighted, resting state (RS) functional MRI and clinical evaluations were obtained from 1754 MS patients (65 clinically isolated syndromes [CIS], 1338 relapsing-remitting [RR] and 351 progressive [P] MS) and 597 healthy controls (HC). Parallel independent component analysis (P-ICA) on GM volume and degree centrality maps produced structural/functional network components and corresponding Z-scores.
P-ICA identified six structural GM networks with significant atrophy in MS patients vs HC (p range <0.001-0.03). CIS patients showed atrophy in the default-mode network (DMN) (p<0.001), RRMS had additional atrophy in occipital, deep GM, and fronto-parietal networks (all p<0.001), while PMS exhibited further atrophy in DMN (p=0.002) and occipital network (p=0.01). P-ICA also identified three sensorimotor networks showing increased functional connectivity (FC) in MS patients vs HC (p=range 0.007/<0.001), while the DMN, fronto-parietal and salience networks showed decreased FC (all p<0.001). CIS patients presented limited FC abnormalities, while more pronounced decrease FC in PMS vs RRMS was found in the DMN (p=0.004) and fronto-parietal (p=0.005) networks. In MS, most of networks showed decreased structural-functional association (interaction p range=0.04 to <0.001), correlating with more severe clinical disability.
Multimodal analysis of structural/functional brain network helped to unravel complex changes of human network organization associated with MS disease.
Authors/Disclosures
Tetsu Morozumi, PT (Ospedale San Raffaele S.r.l.)
PRESENTER 		Mr. Morozumi has nothing to disclose.
Maria A. Rocca (Neuroimaging Research Unit) Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Paola Valsasina Paola Valsasina has nothing to disclose.
Paolo Preziosa (Ospedale San Raffaele) Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb . Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Nicolò Tedone (San Raffaele hospital) Nicolò Tedone has nothing to disclose.
Menno M. Schoonheim, PhD (Amsterdam University Medical Center) The institution of Dr. Schoonheim has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Novartis. The institution of Dr. Schoonheim has received research support from Dutch MS Research Foundation. The institution of Dr. Schoonheim has received research support from Eurostars-EUREKA. The institution of Dr. Schoonheim has received research support from Amsterdam Neuroscience. Dr. Schoonheim has received research support from ZonMW. The institution of Dr. Schoonheim has received research support from Atara Biotherapeutics. The institution of Dr. Schoonheim has received research support from Biogen. The institution of Dr. Schoonheim has received research support from BMS. The institution of Dr. Schoonheim has received research support from Merck. The institution of Dr. Schoonheim has received research support from Cervomed/EIP. The institution of Dr. Schoonheim has received research support from ECTRIMS.
Antonio Gallo Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis.
Patrizia Pantano Patrizia Pantano has nothing to disclose.
Christian Enzinger Christian Enzinger has nothing to disclose.
Sara Llufriu Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merci. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbot. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi.
Massimiliano Calabrese (The Multiple Sclerosis Center, University Hospital of Verona) Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis Pharma. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck Serono. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis Pharma. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Massimiliano Calabrese has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for BMS Celgene. The institution of Massimiliano Calabrese has received research support from Roche.
Giuseppe Pontillo, MD Dr. Pontillo has nothing to disclose.
Einar A. Hogestol, MD, PhD Dr. Hogestol has nothing to disclose.
Sergiu Groppa, Sr. Prof. Groppa has nothing to disclose.
Nicola De Stefano, MD (University of Siena) Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck Healthcare KGaA. Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Immunic AG. Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis Pharma AG. Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck Serono S.p.A. Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Dr. De Stefano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche S.p.A.. The institution of Dr. De Stefano has received research support from Italian MS Society. The institution of Dr. De Stefano has received research support from Merck Healthcare KGaA.
Sara Collorone (UCL Institute of Neurology) The institution of Sara Collorone has received research support from Rosetreest Trust. The institution of Sara Collorone has received research support from MAGNIMS/ECTRIMS.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.