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Abstract Details

Pregnancy Outcomes in Women with Autoimmune Rheumatologic Diseases with and without Neurologic Involvement
Autoimmune Neurology
P5 - Poster Session 5 (11:45 AM-12:45 PM)
2-010
To evaluate pregnancy outcomes in women with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), Behçet’s disease (BD) and sarcoidosis, with and without neurologic involvement.
Pregnancy in women with autoimmune rheumatologic diseases carries increased maternal and neonatal risks. Neurological involvement, seen in SLE, BD, SS, and sarcoidosis, may further worsen reproductive outcomes, yet existing data is very limited.
This is an ongoing retrospective cohort study at Mass General Brigham (2010–2025). Women ≥18 years with one of four autoimmune conditions, pregnancy with known outcomes, and presence or absence of neurologic involvement within 12 months pre-pregnancy and/or intrapartum, are included. Subjects will be matched 1:1 based on autoimmune condition, age, parity status, other co-morbidities, and neurologic involvement.  The data includes demographics, rheumatologic disease activity, medication use, and maternal/fetal outcomes. Planned analyses will include descriptive statistics for baseline characteristics. Categorical outcomes (e.g., miscarriage, preeclampsia, NICU admission) will be compared using chi-square or Fisher’s exact tests. Continuous outcomes (e.g., birth weight, gestational age) will be analyzed with t-tests or Mann–Whitney U tests. Multivariable regression models will adjust for confounders including age, disease activity, medication use, and comorbidities. Statistical significance will be set at p<0.05

Data collection and analysis are currently in progress. Identified cases to date show diverse neurological involvement, including seizures, myelitis, and cerebrovascular events. Final analysis will compare maternal outcomes (miscarriage, preeclampsia, preterm delivery) and neonatal outcomes (low birth weight, neonatal intensive care unit (NICU) admission, infections, other perinatal complications) between women with and without neurological disease, and will be presented during the conference.

This study will provide the first systematic comparison of pregnancy outcomes in women with rheumatologic diseases with and without neurological involvement. Findings may guide counseling, risk stratification, and management strategies for this high-risk population.
Authors/Disclosures
Maria K. Houtchens, MD
PRESENTER 		Dr. Houtchens has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Houtchens has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche . Dr. Houtchens has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Houtchens has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Serono. Dr. Houtchens has received personal compensation in the range of $500-$4,999 for serving as a Consultant for TG Therapeutics. Dr. Houtchens has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Cravath. Dr. Houtchens has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Beasley . Dr. Houtchens has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Biogen. The institution of Dr. Houtchens has received research support from Genzyme. The institution of Dr. Houtchens has received research support from Biogen. The institution of Dr. Houtchens has received research support from Genentech. The institution of Dr. Houtchens has received research support from Novartis.
Tal Friedman Korn, MD Dr. Friedman Korn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.
Shamik Bhattacharyya, MD, FAAN (Brigham and Women's Hospital) Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NeuroLambda. Dr. Bhattacharyya has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion Pharmaceuticals. Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TG Therapeutics. Dr. Bhattacharyya has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Continuum. Dr. Bhattacharyya has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. Dr. Bhattacharyya has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Merck. The institution of Dr. Bhattacharyya has received research support from Alexion Pharmaceuticals. The institution of Dr. Bhattacharyya has received research support from National Institute of Health. The institution of Dr. Bhattacharyya has received research support from UCB. The institution of Dr. Bhattacharyya has received research support from Genentech. Dr. Bhattacharyya has received publishing royalties from a publication relating to health care. Dr. Bhattacharyya has received publishing royalties from a publication relating to health care.
Mattia Wruble, MD The institution of Dr. Wruble has received research support from Alexion. The institution of Dr. Wruble has received research support from Roche.
Giovanna Manzano, MD Dr. Manzano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gilead Sciences. Dr. Manzano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for InfuCare Rx.