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Abstract Details

Cranial Magnetic Resonance Imaging Findings in Methanol Poisoning: Systematic Review and Meta-analysis of Radiological Prevalence
General Neurology
P5 - Poster Session 5 (11:45 AM-12:45 PM)
7-007
This meta-analysis aimed to evaluate the pooled prevalence of key cranial magnetic resonance imaging (MRI) findings in methanol poisoning, including putaminal necrosis, optic nerve injury, and mortality.
Methanol intoxication is a potentially fatal condition causing severe neurological deficits, yet the prevalence and clinical implications of MRI-detected brain lesions remain incompletely characterized. 

A systematic review and meta-analysis were conducted following PRISMA 2020 and Cochrane Handbook guidelines. Eligible studies reporting MRI findings in patients with confirmed methanol poisoning were retrieved from Medline, Scopus, and Web of Science. A random-effects model was used to pool proportions, and heterogeneity was quantified using the I² statistic.

Fifteen studies encompassing 3–58 patients each were included (total n = 163). Patients were predominantly male, aged 17–77 years, with oral ingestion as the primary exposure route. Mortality was reported in 7 studies, with a pooled prevalence of 7.8% (95% CI 2.2–24.1; I² = 53.9%). Optic nerve injury was reported in 4 studies, with a pooled prevalence of 36.1% (95% CI 9.2–75.8; I² = 84.0%). Putaminal necrosis, the most frequent MRI finding, was reported in 8 studies, with a pooled prevalence of 47.6% (95% CI 30.3–65.6; I² = 75.0%).
MRI abnormalities are highly prevalent in methanol poisoning. Putaminal necrosis represents the hallmark radiologic feature, while optic nerve injury is present in roughly one-third of cases. Despite moderate to high heterogeneity among studies, these findings reinforce MRI as a critical tool for assessing methanol-induced neurotoxicity and predicting clinical outcomes.
Authors/Disclosures
Vitoria Palazoni Viegas
PRESENTER 		Dr. Palazoni Viegas has nothing to disclose.
Rebeca O. Silva, Student Miss Silva has nothing to disclose.
Bianca N. Aguirre, MD Dr. Aguirre has nothing to disclose.
Othon T. Meira, MD Dr. Meira has nothing to disclose.
Pedro Lívio Gomes Moura Mr. Gomes Moura has nothing to disclose.
Victor Arthur A. Ohannesian, MS Mr. Ohannesian has nothing to disclose.
Cid Soares, MS Mr. Soares has nothing to disclose.
Beatriz Gerente, Medical Student Miss Gerente has nothing to disclose.
Diogo Haddad Santos, MD (Moema) Dr. Haddad Santos has nothing to disclose.