Abstract Details

Title Do Low Vitamin D Levels in Patients with Epilepsy Correlate to Mood Disorders and Quality of Life?

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P6 - Poster Session 6 (5:00 PM-6:00 PM)

Poster/Presentation
Number 10-007

Objective Our objective was to determine if low vitamin D levels in our NeuroMeasures™ data set correlated with worsening mood, fatigue, anxiety and QOL.

Background Studies of epilepsy populations show consistent evidence of widespread Vitamin D deficiency with potential benefits of supplementation on mood, fatigue mitigation, and quality of life (QOL).

Design/Methods We conducted a retrospective chart review of 25-hydroxyvitamin D (25(OH)D) levels obtained in 515 patient visits (370 unique patients) from the NeuroMeasures™ dataset. Levels were collected within 8 weeks of survey visit. We collected the survey results for Quality Of Life In Epilepsy 10P (QOLIE-10-p, lower score on a continuous scale suggests lower QOL), Neurological Disorders Depression Inventory in Epilepsy (NDDI-E ≥ 15 associated with major depression disorder), Fatigue Severity Scale (FSS ≥ 36 associated with higher fatigue), and Generalized Anxiety Disorder 7 (GAD-7, moderate anxiety score is 5-9; severe anxiety score is 10-14). We compared 25(OH)D) levels and survey results using Pearson correlation coefficients (significant at the 0.01 level [2-tailed]).

Results Of 515 unique patient surveys, we identified 88 records in 62 unique patients with 25(OH)D levels where at least one of the four surveys was completed. The average 25(OH)D level was 26.9 ng/mL (range: <7 to 67) and 55 records had levels below 30 ng/mL (low). Low 25(OH)D levels were not significantly correlated with QOLIE-10-p (n=82, Pearson r= -0.117, p=0.293), NDDI-E (n=85, Pearson r =-.016, p=0.883), FSS (n=83, Pearson r = -.030, p=0.793), and GAD-7 (n=78, Pearson r = -0.143, p=0.185).

Conclusions We did not find a correlation in our cohort between lower 25(OH)D levels and lower quality of life and higher depression, anxiety, and fatigue scores. Limitations include small sample size, retrospective review and lack of analysis regarding Vitamin D replacement. Larger prospective studies in Vitamin D’s role in epilepsy care may provide more information.

Authors/Disclosures
Harneet Sidhu, DO PRESENTER	Dr. Sidhu has nothing to disclose.
Muhanned S. Abdallah, MD (Detroit Medical Center (DMC))	Dr. Abdallah has nothing to disclose.
Maysaa M. Basha, MD, FAAN (Wayne State University, Detroit Medical Center)	Dr. Basha has nothing to disclose.
Rohit A. Marawar, MD, FAAN (Wayne State University - Detroit Medical Center)	Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz Pharmaceuticals. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SK Pharma. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Xenon. Dr. Marawar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis.
Scott Millis	Scott Millis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Taylor & Francis. The institution of Scott Millis has received research support from NIH & NIDILRR.
Deepti Zutshi, MD, FAAN (Wayne State University School of Medicine)	Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xenon pharmaceuticals. An immediate family member of Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aucta Pharmaceuticals. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aucta.

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