Abstract Details

Title Demographics and Comorbidities of Patients With Narcolepsy: A Propensity Score–Matched Cohort Study

Topic Sleep

Presentation(s) P6 - Poster Session 6 (5:00 PM-6:00 PM)

Poster/Presentation
Number 14-010

Objective This study used aggregate electronic health record (EHR) data to characterize the demographics and comorbidities of patients with narcolepsy.

Background Narcolepsy is a rare, chronic sleep disorder associated with decreased quality of life and multiple comorbid conditions.

Design/Methods

An EHR-based search identified first-time Duke Health patients between January 1, 2012, to March 31, 2024. Included patients had ≥1 narcolepsy-specific ICD-9 (347.*) and ICD-10 (G47.4*) codes and ≥1 disease-supportive statement in clinical notes, identified using a natural language processing algorithm. A control cohort was propensity-matched for birth year, age at first institutional encounter, sex, race, number of diagnosis code instances, and mortality. Common comorbidities were compared and ranked between cohorts by odds ratio (OR). Statistical significance was determined using a chi-squared test; P values were corrected for multiple comparisons using Bonferroni correction.

Results Within the EHR database of 2,617,188 patients, 1659 patients with a narcolepsy diagnosis were identified (mean age at first presentation, 32.4 years; white, 69%; female, 69%); the propensity-matched control cohort included 1659 patients (mean age at first presentation, 32.3 years; white, 69%; female, 69%). Comorbidities that occurred statistically significantly more frequently (all P<0.0001) among the narcolepsy vs control cohort (OR [95% CI]) included sleep disorders: sleep-related movement disorders (26.26 [10.71, 64.40]), hypersomnia (16.56 [12.54, 21.87]), circadian rhythm sleep disorders (15.43 [6.73, 35.38]); psychiatric or mood disorders: post-traumatic stress disorder (3.08 [2.10, 4.52]), attention deficit hyperactivity disorder (2.90 [2.28, 3.68]), depression (2.66 [2.27, 3.11]); and pain disorders: trigeminal neuralgia (6.63 [2.80, 15.70]), fibromyalgia (5.30 [3.58, 7.85]), chronic pain syndrome (3.37 [2.46, 4.61]. Postural orthostatic tachycardia syndrome occurred statistically significantly more frequently in the narcolepsy vs control cohort (7.24 [3.59, 14.61]).

Conclusions Consistent with prior EHR research, sleep, psychiatric, and pain disorders were among the most frequently reported comorbidities of patients with narcolepsy.

Authors/Disclosures
Ketul Patel PRESENTER	Ketul Patel has received personal compensation for serving as an employee of Avadel Pharmaceuticals.
Marjorie Soltis, MD (Duke University Medical Center)	Dr. Soltis has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Jazz Pharmaceuticals.
Melissa C. Lipford, MD (Mayo Clinic)	Dr. Lipford has nothing to disclose.
Allison Smither, PhD	Dr. Smither has received personal compensation for serving as an employee of nference.
Jennifer Gudeman (Avadel Pharmaceuticals)	Miss Gudeman has received personal compensation for serving as an employee of Avadel Pharmaceuticals. Miss Gudeman has stock in Avadel Pharmaceuticals.

��ɫ��

��ɫ��