Abstract Details

Title Effects of a 16-Week Aerobic Exercise Program on Motor and Non-motor Symptoms (NMS) of Parkinson’s Disease (PD)

Topic Movement Disorders

Presentation(s) P6 - Poster Session 6 (5:00 PM-6:00 PM)

Poster/Presentation
Number 17-006

Objective

Assess the effects of a 16-week aerobic exercise program on motor and non-motor symptoms (NMS) of Parkinson’s disease (PD).

Background Aerobic exercise has been investigated as a therapeutic intervention for PD and is associated with improvement in motor function. However, its effects on distinct aspects of gait, balance, and mobility remain poorly understood. Furthermore, NMS represent a substantial burden for people with PD (PwP), yet prior studies examining the impact of aerobic exercise on NMS have been limited in scope and yielded inconsistent results.

Design/Methods In this pre-post intervention study, PwP completed supervised, high-intensity and unsupervised, moderate-intensity aerobic exercise for 5 days per week. Subjects completed gait and balance assessments, neuropsychological testing, and non-motor symptom questionnaires evaluating sleep, fatigue, somnolence, and mood. Subjects’ scores were compared between baseline and post-intervention using paired sample t-tests.

Results Twenty-four participants completed the intervention; fifteen were female (62.5%). The mean age was 68.1 years (SD=5.7), the mean duration of disease was 5.2 years (SD=5.1), and the mean MDS-UPDRS Part III score was 28.3 (SD=9.6). Mean pre-post intervention score change (?¯) on the Epworth Sleepiness Scale (?¯=2.00, 95% CI [0.54, 3.46], p=0.005) and Beck Depression Inventory (?¯=1.52, 95% CI [0.46, 2.59], p=0.005) improved. Subjects showed improvement on the Short Physical Performance Battery (?¯=-0.75, 95% CI [-1.17, -0.33], p=0.001). We observed no statistically significant differences in the remaining assessments.

Conclusions Aerobic exercise offers selective improvement in non-motor symptoms and functional mobility. Its recommendation to patients may thus improve quality of life, lessen medication burden, and reduce risk of falls. To our knowledge, this is the first study to evaluate the effects of aerobic exercise on somnolence in PD. In contrast to prior research, aerobic exercise did not evidence improvement in any cognitive domain. Controlled studies with larger samples are warranted to confirm these findings and clarify mechanisms underlying these effects.

Authors/Disclosures
Joseph Flanigan PRESENTER	Joseph Flanigan has nothing to disclose.
Diane S. Huss, PT	Dr. Huss has nothing to disclose.
James Patrie (University of Virginia)	James Patrie has nothing to disclose.
William A. Dalrymple, MD (University of Virginia Health System)	Dr. Dalrymple has received personal compensation in the range of $500-$4,999 for serving as a Consultant for REACH. Dr. Dalrymple has received personal compensation in the range of $0-$499 for serving as a Consultant for M3. Dr. Dalrymple has received personal compensation in the range of $0-$499 for serving as a Consultant for Boxer Capital. Dr. Dalrymple has received personal compensation in the range of $0-$499 for serving as a Consultant for Capvision. Dr. Dalrymple has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Atheneum. Dr. Dalrymple has received personal compensation in the range of $0-$499 for serving as a Consultant for Cencora. Dr. Dalrymple has received personal compensation in the range of $0-$499 for serving as a Consultant for Lumanity. Dr. Dalrymple has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Huntington Study Group. Dr. Dalrymple has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Huntington Study Group. The institution of Dr. Dalrymple has received research support from Huntington's Disease Society of America.
Renzo Figari-Jordan, MD, FAAN (University of Virginia)	Dr. Figari-Jordan has nothing to disclose.
Kristina M. Cain, MD	Dr. Cain has nothing to disclose.
Matthew J. Barrett, MD, FAAN (Virginia Commonwealth University)	The institution of Dr. Barrett has received research support from Kyowa Kirin. The institution of Dr. Barrett has received research support from NIH.
Binit Shah, MD, FAAN (University of Virginia)	Dr. Shah has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Expert Institute.

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