Abstract Details

Title Artifactual Signal Detection Using Intraoperative Electrocorticographic Devices During Functional Brain Mapping of Brain Tumor

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P7 - Poster Session 7 (8:00 AM-9:00 AM)

Poster/Presentation
Number 10-004

Objective

To compare the signal detection performance of a customized circular grid and a strip electrode during intraoperative electrocorticography (iECoG) during functional brain mapping (FBM).

Background

Intraoperative ECoG is commonly used during awake craniotomy to assist with functional brain mapping and guide safe tumor resection. However, variability in electrode design may influence signal quality and sensitivity to stimulation-related artifacts or physiologic responses. High-density circular grids may offer improved spatial coverage and detection capabilities, but comparative data with conventional strip electrodes remain limited.

Design/Methods

We performed a single center retrospective evaluation of signal detection by recording intraoperative ECoG comparing a 22-channel high-density circular grid and commercial 1 x 6 linear strip. We quantified physiological and nonphysiological measures involving direct electrical stimulation (DES) artifact, afterdischarges (ADs), and epileptiform activity in patients with brain tumors.

Results 142 patients underwent awake craniotomy with FBM and iECoG. 26 (18.3%) had reoperations with iECoG. A total of 71 patients had iECoG using circular grids, and 71 with linear strips. Maximum and minimum signal amplitudes of DES artifact were higher with the circular grid (p <0.01). The minimum (2.3 vs. 2.8 mA) and maximum (4.9 vs. 6.3 mA) currents required to evoke DES artifact were lower with the circular grid (p < 0.01). Physiological signals represented by ADs were more frequently detected with the circular grid (182 vs. 82, p = 0.004) and involved more electrodes (5.06 vs. 0.95, p < 0.001).

Conclusions

High-density circular grids had increased sensitivity to physiological and non-physiological signals with lower DES currents required for detection.

Authors/Disclosures
William O. Tatum IV, DO, FAAN (Mayo Clinic) PRESENTER	Dr. Tatum has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bioserenity. Dr. Tatum has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Natus. Dr. Tatum has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurelis. Dr. Tatum has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Tatum has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Defense Law Firm on behalf of a patient with epilepsy with funds donated to the Epilepsy Foundation of America. The institution of Dr. Tatum has received research support from Esai. The institution of Dr. Tatum has received research support from Mayo Clinic. The institution of Dr. Tatum has received research support from Liva Nova. The institution of Dr. Tatum has received research support from Engage Pharmaceuticals. The institution of Dr. Tatum has received research support from Xenon. Dr. Tatum has received intellectual property interests from a discovery or technology relating to health care. Dr. Tatum has received publishing royalties from a publication relating to health care. Dr. Tatum has received publishing royalties from a publication relating to health care. Dr. Tatum has received publishing royalties from a publication relating to health care. Dr. Tatum has a non-compensated relationship as a AAN Section Chair of Clinical Neurophysiology with AAN that is relevant to AAN interests or activities.
Adrian Safa, MD	Dr. Safa has nothing to disclose.
Filippo Emanuele Colella	Mr. Colella has nothing to disclose.
Erik Middlebrooks	Erik Middlebrooks has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Boston Scientific Corp. Erik Middlebrooks has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Siemens Healthineers. Erik Middlebrooks has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Journal of Neuroradiology.
Anteneh M. Feyissa, MD, MSc, FAAN (Mayo Clinic)	Dr. Feyissa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Neurelis.
Aafreen Khan, MD	Dr. Khan has nothing to disclose.
David Sabsevitz	No disclosure on file
Alicia Kissinger-Knox, PsyD	Dr. Kissinger-Knox has nothing to disclose.
Phillip Gauthier (Mayo Clinic)	No disclosure on file
Dawn Radford, DO	No disclosure on file
Anahita Jafari, MD	Dr. Jafari has nothing to disclose.
Marco Failla Mulone, MD	Dr. Failla Mulone has nothing to disclose.
Sanjeet S. Grewal, MD	Sanjeet S. Grewal, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic.
Kaisorn Chaichana, MD	Dr. Chaichana has nothing to disclose.
Alfredo Quinones-Hinojosa	Alfredo Quinones-Hinojosa has nothing to disclose.
Brin Freund, MD	Dr. Freund has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Freund has received research support from Mayo Clinic.

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