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Abstract Details

Functional Connectivity Changes Indicate Cerebellar Network Compensation in Early Alzheimer’s Disease
Aging, Dementia, and Behavioral Neurology
P7 - Poster Session 7 (8:00 AM-9:00 AM)
13-013

We examined lobule-specific cerebello-cerebral functional connectivity in early Alzheimer's disease (AD), aiming to i) characterize the reorganization of cerebello-cerebral networks and ii) assess whether these connectivity changes reflect compensatory recruitment to sustain cognition in early AD.
The cerebellum is increasingly recognized as a key contributor to cognitive networks. Prior work suggests compensatory cerebellar involvement in mild cognitive impairment, the prodromal stage of AD. Whether such compensation persists into early clinical AD remains unknown.
Twenty early AD (Mini-Mental Status Exam score of 22 to 28) and 19 cognitively normal participants underwent resting-state functional MRI. Seed-based functional connectivity analyses were performed for individual cerebellar lobules, with between-group comparison and correlations with clinical measures, including Clinical Dementia Rating–Sum of Boxes(CDR-SB) and 13- item AD Assessment Scale-Cognitive(ADAS-Cog).
Early AD participants showed reduced cerebello-thalamic and cerebello-parietal functional connectivity; however, greater functional connectivity was identified between the cerebellum (lobule III, VI, and VIIb) and the i) cerebral sensorimotor (e.g., the postcentral and precentral gyrus), ii) auditory (e.g., the Heschl's gyrus), and iii) paralimbic cortices. This indicates a shift away from canonical associative loops toward recruitment of additional, noncanonical networks. Stronger functional connectivity was significantly correlated with cognitive subdomain of orientation, constructional praxis, and command, rather than global severity. In controls, the association between cerebello-cerebral functional connectivity and cognition primarily involved canonical frontoparietal and temporal networks. By contrast, in early AD, these relationships shifted toward noncanonical networks in limbic and paralimbic regions.
Early AD is marked by lobule-specific reorganization of cerebello-cerebral networks, displayed as weakening of canonical loops with compensatory recruitment of alternative circuits. These findings highlight the cerebellum’s ongoing role in sustaining cognition despite cerebral cortical networks become disrupted in early AD. Our results suggests that stage- and domain-specific cerebellar connectivity may serve as a novel imaging biomarker of the cerebellum-driven compensatory network in early AD.
Authors/Disclosures
Chi-Ying (Roy) Lin, MD, FAAN (Baylor College of Medicine)
PRESENTER 		Dr. Lin has received research support from Texas Alzheimer's Research and Care Consortium (TARCC). Dr. Lin has received research support from CurePSP. Dr. Lin has received research support from Mike Hogg Fund. Dr. Lin has received research support from The Michael J. Fox Foundation Parkinson's Progression Markers Initiative (PPMI). Dr. Lin has a non-compensated relationship as a Secretary with Broadway for Ataxia Foundation (a 501 (c) (3) non-profit organization) that is relevant to AAN interests or activities.
Shayla Yonce (Baylor College of Medicine) Shayla Yonce has nothing to disclose.
Hyuntaek Oh, PhD Dr. Oh has nothing to disclose.
Melissa Yu, MD, FAAN An immediate family member of Dr. Yu has received personal compensation for serving as an employee of CVS/Aetna. The institution of Dr. Yu has received research support from Alzheimer's Association. The institution of Dr. Yu has received research support from Biogen. The institution of Dr. Yu has received research support from Eisai. The institution of Dr. Yu has received research support from Novo Nordisk. The institution of Dr. Yu has received research support from Suven. The institution of Dr. Yu has received research support from AriBio. Dr. Yu has received personal compensation in the range of $500-$4,999 for serving as a advisory board member with Eli Lilly.
Jonathan D. Sober, PhD Dr. Sober has nothing to disclose.
Valory Pavlik, PhD (Baylor College of Medicine) The institution of Dr. Pavlik has received research support from Alzheimer's Association.
Ramiro Salas (Baylor College of Medicine) The institution of Ramiro Salas has received research support from VHA. The institution of Ramiro Salas has received research support from Wallace foundation.